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108975 Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem

108975
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
103476-89-7C₂₀H₃₈N₆O₄ . 1/2H₂SO₄

Products

产品目录编号包装 数量 / 包装
108975-100MGCN 塑胶安瓿;塑胶针药瓶 100 mg
108975-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
108975-25MGCN 塑胶安瓿;塑胶针药瓶 25 mg
108975-50MGCN 玻璃瓶 50 mg
108975-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune responses of HIV+ donors. Also available as a 50 mM solution in H2O (Cat. No. 509281).
Catalogue Number108975
Brand Family Calbiochem®
SynonymsAc-LLR-CHO, ½H₂SO₄
References
ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Product Information
CAS number103476-89-7
ATP CompetitiveN
FormWhite lyophilized solid
Hill FormulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary Targettrypsin- and cysteine-like proteases
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
108975-100MGCN 04055977208535
108975-10MGCN 04055977208528
108975-25MGCN 07790788047757
108975-50MGCN 04055977208580
108975-5MGCN 04055977208573

Documentation

Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Leupeptin, Hemisulfate, Microbial - CAS 103476-89-7 - Calbiochem 分析证书

标题批号
108975

参考

参考信息概述
Montenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
Sarin, A., et al. 1994. J. Immunol. 153, 862.

小册子

标题
Bulk Product Guide
Caspases and other Apoptosis Related Tools Brochure

引用

标题
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
  • 数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision29-March-2010 JSW
    SynonymsAc-LLR-CHO, ½H₂SO₄
    DescriptionA reversible inhibitor of trypsin-like proteases and cysteine proteases. Also known to inhibit activation-induced programmed cell death and to restore defective immune response in HIV+ donors. Often used for the inhibition of endoproteinase Lys-C, kallikrein, papain, plasmin, thrombin, cathepsin B, and trypsin. Leupeptin does not inhibit chymotrypsin, elastase, renin, or pepsin. The recommended working range is 10-100 µM for most applications.
    FormWhite lyophilized solid
    CAS number103476-89-7
    Chemical formulaC₂₀H₃₈N₆O₄ . 1/2H₂SO₄
    Peptide SequenceAc-Leu-Leu-arginal, hemisulfate
    Structure formulaStructure formula
    Purity≥90% by HPLC
    SolubilityH₂O (50 mg/ml)
    Storage -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Aqueous stock solutions are stable for up to 1 week at 4°C or for up to 1 month at -20°C.
    Toxicity Standard Handling
    Merck USA index14, 5456
    ReferencesMontenez, J.P., et al. 1994. Toxicol. Lett. 73, 201.
    Sarin, A., et al. 1994. J. Immunol. 153, 862.
    Citation
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.