Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

438210 LSF Inhibitor, FQI1 - Calbiochem

The LSF Inhibitor, FQI1 controls the biological activity of LSF.

LSF Inhibitor, FQI1 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: (±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic

438210
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

Empirical Formula
C₁₈H₁₇NO₄

Products

产品目录编号包装 数量 / 包装
438210-10MGCN 玻璃瓶 10 mg
Description
OverviewA cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
Catalogue Number438210
Brand Family Calbiochem®
Synonyms(±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
Application Data
References
ReferencesGrant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.
Product Information
FormWhite powder
Hill FormulaC₁₈H₁₇NO₄
Chemical formulaC₁₈H₁₇NO₄
Quality LevelMQ100
Applications
Biological Information
Purity>92% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
438210-10MGCN 04055977187052

Documentation

LSF Inhibitor, FQI1 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

LSF Inhibitor, FQI1 - Calbiochem 分析证书

标题批号
438210

参考

参考信息概述
Grant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-September-2012 JSW
Synonyms(±)(8-(2-Ethoxyphenyl)-7,8-dihydro-[1,3]dioxolo[4,5-g]quinolin-6(5H)-one, Factor Quinolinone Inhibitor 1, Racemic
Application Data
DescriptionA cell-permeable dihydroquinolinone compound that acts as a potent, specific, and reversible inhibitor of DNA-binding activity of Late SV40 Factor (LSF) and blocks LSF transactivation (IC50 = 2.1 µM in NIH 3T3 cells). Exhibits anti-proliferative activity and growth arrest in multiple cell lines (GI50 = 3.8, 0.79, and 6.3 µM in NIH 3T3, HeLa S3 and A549 cells, respectively). Shown to induce apoptotic cell death in liver cancer cell lines over-expressing LSF without affecting primary or immortalized hepatocytes. Also shown to inhibit hepatocellular carcinoma s.c. growth in mouse xenograft model without any toxic effects (1 mg/kg, i.p., once every 3 days).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₇NO₄
Purity>92% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesGrant, T.J., et al. 2012. Proc. Natl. Acad. Sci. USA 109, 4503.