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422711 KN-93, Water-Soluble - Calbiochem

This KN-93 is a water-soluble version of KN-93 that acts as a reversible and competitive inhibitor of CaM kinase II (Ki = 370 nM for rat brain).

KN-93, Water-Soluble - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Calmodulin-Dependent Protein Kinase (CaM Kinase) 2
422711
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概述

Replacement Information

重要规格表

Empirical Formula
C₂₆H₂₉ClN₂O₄S · H₃PO₄

Products

产品目录编号包装 数量 / 包装
422711-1MGCN 玻璃瓶 1 mg
Description
OverviewA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Also available as a 5 mM solution in H2(Cat. No. 508315).
Catalogue Number422711
Brand Family Calbiochem®
References
ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCalmodulin-Dependent Protein Kinase (CaM Kinase) 2
Primary Target K<sub>i</sub>370 nM for cam kinase 2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
422711-1MGCN 04055977187274

Documentation

KN-93, Water-Soluble - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

KN-93, Water-Soluble - Calbiochem 分析证书

标题批号
422711

参考

参考信息概述
Tombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision05-August-2008 RFH
DescriptionA water-soluble form of the CaM kinase II inhibitor KN-93 (Cat. No. 422708). Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets of Langerhans. Has no significant effect on protein kinase A activity. Induces G1 cell cycle arrest and apoptosis in NIH 3T3 cells.
FormWhite solid
Chemical formulaC₂₆H₂₉ClN₂O₄S · H₃PO₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityH₂O (5 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesTombes, R.M., et al. 1995. Cell Growth Differ. 6, 1063.
Chen, C., et al. 1994. Science 266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun. 195, 608.
Nicki, I., et al. 1993. Biochem. Biophys. Res. Commun. 191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun. 181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem. 265, 4315.