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420143 JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem

The JNK3 Inhibitor XII, SR-3576, also referenced under CAS 1164153-22-3, controls the biological activity of JNK3. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide

420143
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
1164153-22-3C₂₇H₂₇N₅O₅

Products

产品目录编号包装 数量 / 包装
420143-5MGCN 玻璃瓶 5 mg
Description
OverviewA cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 µM).
Catalogue Number420143
Brand Family Calbiochem®
Synonyms3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
References
ReferencesKamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.
Product Information
CAS number1164153-22-3
FormOff-white solid
Hill FormulaC₂₇H₂₇N₅O₅
Chemical formulaC₂₇H₂₇N₅O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25

Do not breathe dust.
Avoid contact with skin and eyes.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
420143-5MGCN 04055977211092

Documentation

JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem 分析证书

标题批号
420143

参考

参考信息概述
Kamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms3-(4-(3-(3-Methylphenylureido))-1H-pyrazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide
DescriptionA cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 µM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 µM).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1164153-22-3
Chemical formulaC₂₇H₂₇N₅O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKamenecka, T., et al. 2009. J. Biol. Chem. 284, 12853.