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420104 JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem

420104
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
211555-04-3C₁₆H₁₄BrN₃O₃

Products

产品目录编号包装 数量 / 包装
420104-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3 (IC50 = 5.6 µM). Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-Jun in DT-40 cells. Also acts as a potent inhibitor of glioblastoma cell adhesion and migration.
Catalogue Number420104
Brand Family Calbiochem®
Synonyms4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
References
ReferencesGhosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.
Product Information
CAS number211555-04-3
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₁₆H₁₄BrN₃O₃
Chemical formulaC₁₆H₁₄BrN₃O₃
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetJAK-3
Primary Target IC<sub>50</sub>5.6 µM against JAK3
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
420104-5MGCN 04055977187908

Documentation

JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

JAK3 Inhibitor II - CAS 211555-04-3 - Calbiochem 分析证书

标题批号
420104

参考

参考信息概述
Ghosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.

技术信息

标题
JAK/STAT Signaling Research Focus
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-January-2010 RFH
Synonyms4-[(3ʹ-Bromo-4ʹ-hydroxyphenyl)amino]-6,7-dimethoxyquinazoline, WHI-P154
DescriptionA potent, cell-permeable, reversible, ATP-competitive, and specific inhibitor of JAK3. Has no effect on either JAK1 or JAK2. Has also been shown to prevent the ionizing radiation-induced activation of c-jun in DT-40 cells.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number211555-04-3
Chemical formulaC₁₆H₁₄BrN₃O₃
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGhosh, S., et al. 2001. Acta Crystallogr. C. 57, 76.
Sudbeck, E.A., et al. 1999. Clin. Cancer Res. 5, 1569.
Goodman, P.A., et al. 1998. J. Biol. Chem. 273, 17742.
Narla, R.K., et al. 1998. Clin Cancer Res. 4, 2463.