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407652 Interleukin-6, Human, Recombinant, E. coli

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: rhIL-6

407652
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概述

Replacement Information

Products

产品目录编号包装 数量 / 包装
407652-10UGCN 塑胶安瓿;塑胶针药瓶 10 μg
Description
OverviewRecombinant, human, interleukin-6 expressed in E. coli. A prototypic pleiotrophic, pro-inflammatory cytokine that stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B cells, T cells, and hepatocytes. Stimulates growth and inhibits constitutive, protein synthesis-independent apoptosis of murine B cell hybridoma 7TD1. IL-6 is produced by macrophages, endothelial cells, and activated T helper cells. Also considered as a potential marker of adipocyte differentiation. Human IL-6 is active on murine cells.
Catalogue Number407652
Brand Family Calbiochem®
SynonymsrhIL-6
References
ReferencesVicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
Liu, J., et al. 1994. Cell Immunol. 155, 229.
Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.
Product Information
FormLyophilized
FormulationCarrier free.
Quality LevelMQ100
Applications
Biological Information
Biological activity8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
Purity≥95% by SDS-PAGE
Physicochemical Information
ContaminantsEndotoxin: ≤1.0 EU/µg IL-6
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
407652-10UGCN 04055977211405

Documentation

Interleukin-6, Human, Recombinant, E. coli MSDS

职位

物料安全数据表 (MSDS) 

Interleukin-6, Human, Recombinant, E. coli 分析证书

标题批号
407652

参考

参考信息概述
Vicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
Liu, J., et al. 1994. Cell Immunol. 155, 229.
Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-October-2007 JSW
SynonymsrhIL-6
DescriptionRecombinant, human, interleukin-6 expressed in E. coli. Interleukin-6 is a protein produced by a number of cell types including T-lymphocytes, monocytes, diploid fibroblasts, hepatocytes, cardiac myxomas, certain cervical cancer cells, bladder cell carcinomas, vascular endothelial cells, and human myelomas. It has a variety of biological effects and does not show a high degree of species specificity. Stimulates the production of acute phase proteins by hepatocytes. Also known to induce skeletal muscle protein breakdown. Induces growth and differentiation of B-cells, T-cells, and hepatocytes. Stimulates growth and inhibits constitutive protein synthesis-independent apoptosis of murine B-cell hybridoma 7TD1. Human sequence IL-6 is active on murine cells. 1 µg is equivalent to 7.0 x 103 WHO units.
FormLyophilized
FormulationCarrier free.
Purity≥95% by SDS-PAGE
ContaminantsEndotoxin: ≤1.0 EU/µg IL-6
Biological activity8-20 pg/ml as measured in a cell proliferation assay with a factor-dependent murine plasmacytoma cell line, B9.
SolubilityReconstitute to 0.1-1.0 mg/ml in 100 mM acetic acid.
Storage ≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 3 months at -70°C. Avoid freeze/thaw cycles of solutions.
Toxicity Standard Handling
ReferencesVicennati, V., et al. 2002. Int. J. Obes. Relat. Metab. Disord. 26, 9.
Vallieres, L., and Rivest, S. 1999. Endocrinology 140, 3890.
Goodman, M.N. 1994. Proc. Soc. Exp. Biol. Med. 205, 182.
Liu, J., et al. 1994. Cell Immunol. 155, 229.
Van Snick, J. 1990. Annu. Rev. Immunol. 8, 253.