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444151 InSolution™ Nutlin-3, Racemic - Calbiochem

InSolution™ Nutlin-3, Racemic - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词:  MDM2 Inhibitor IV

444151
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概述

Replacement Information

重要规格表

Empirical Formula
C₃₀H₃₀Cl₂N₄O₄

Products

产品目录编号包装 数量 / 包装
444151-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
Catalogue Number444151
Brand Family Calbiochem®
Synonyms MDM2 Inhibitor IV
References
ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.
Product Information
FormLiquid
FormulationA 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Hill FormulaC₃₀H₃₀Cl₂N₄O₄
Chemical formulaC₃₀H₃₀Cl₂N₄O₄
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26-36-45

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
444151-1MGCN 04055977205466

Documentation

InSolution™ Nutlin-3, Racemic - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

InSolution™ Nutlin-3, Racemic - Calbiochem 分析证书

标题批号
444151

参考

参考信息概述
Thompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-August-2008 JSW
Synonyms MDM2 Inhibitor IV
DescriptionA cell-permeable, potent, and selective MDM2 antagonist (IC50 = 90 nM for Nutlin-3a and 13.6 µM for Nutlin-3b) that displays antitumor properties. Activates the p53 pathway by binding MDM2 in the p53-binding pocket and inhibiting the MDM2-p53 interaction. Shown to induce apoptosis in several cancer cell lines with wild-type p53 and in xenografted tumor mice.
FormLiquid
FormulationA 10 mM (1 mg/172 µl) solution of MDM2 Antagonist, Nutlin-3, Racemic (Cat. No. 444143) in DMSO
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₃₀H₃₀Cl₂N₄O₄
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
-20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Irritant
ReferencesThompson, T., et al. 2004. J. Biol. Chem. 279, 53015.
Vassilev, L.T., et al. 2004. Science 303, 844.