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420127 InSolution™ Jasplakinolide, Jaspis johnstoni - Calbiochem

InSolution™ Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a 1 mM solution of Jasplakinolide, Jaspis johnstoni in DMSO. Acts as a potent inducer of actin polymerization and stabilization.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: F-actin
420127
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概述

Replacement Information

重要规格表

Empirical Formula
C₃₆H₄₅BrN₄O₆

Products

产品目录编号包装 数量 / 包装
420127-50UGCN 塑胶安瓿;塑胶针药瓶 50 μg
Description
Catalogue Number420127
Brand Family Calbiochem®
References
ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.
Hill FormulaC₃₆H₄₅BrN₄O₆
Chemical formulaC₃₆H₄₅BrN₄O₆
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution™ Jasplakinolide, Jaspis johnstoni, CAS 102396-24-7, is a 1 mM solution of Jasplakinolide, Jaspis johnstoni in DMSO. Acts as a potent inducer of actin polymerization and stabilization.
Biological Information
Primary TargetF-actin
Primary Target IC<sub>50</sub>Kd = 15 nM for actin binding
Purity≥90% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
420127-50UGCN 04055977188059

Documentation

InSolution™ Jasplakinolide, Jaspis johnstoni - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

InSolution™ Jasplakinolide, Jaspis johnstoni - Calbiochem 分析证书

标题批号
420127

参考

参考信息概述
Rosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.

引用

标题
  • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-March-2008 JSW
    DescriptionA cell-permeable F-actin probe. This macrocyclic cyclodepsipeptide, isolated from the marine sponge Jaspis johnstoni, is a potent inducer of actin polymerization and stabilization in vitro. It competes with Phalloidin (Cat. No. 516640) for actin binding (Kd = 15 nM) and enhances apoptosis induced by interleukin 2 (IL-2) deprivation. Also displays fungicidal, insecticidal, and anticancer properties.
    FormLiquid
    FormulationA 1 mM (50 µg/71 µl) solution of Jasplakinolide, Jaspis johnstoni (Cat. No. 420107) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₃₆H₄₅BrN₄O₆
    Structure formulaStructure formula
    Purity≥90% by HPLC
    Storage Protect from light
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
    Toxicity Harmful
    ReferencesRosado, J.A., et al. 2000. J. Biol. Chem. 275, 7527.
    Posey, S.C., and Bierer, B.E. 1999. J. Biol. Chem. 274, 4259.
    Senderowicz, A.M., et al. 1995. J. Natl. Cancer Inst. 87, 46.
    Bubb, M.R., et al. 1994. J. Biol. Chem. 269, 14869.
    Scott, V.R., et al. 1988. Antimicrob. Agents Chemother. 32, 1154.
    Citation
  • Markus Utech, et al. (2005) Mechanism of IFN-γ-Induced Endocytosis of Tight Junction Proteins: Mysoin II-Dependent Vacuolarization of the Apical Plasma Membrane. Molecular Biology of the Cell 16, 5040-5052.
    		•