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235427 InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem

The InSolution™ Caspase-3 Inhibitor I, Cell-Permeable controls the biological activity of Caspase-3. This small molecule/inhibitor is primarily used for Cancer applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Cell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable

Primary Target: caspase-3
235427
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

Empirical Formula
C₉₄H₁₅₈N₂₀O₂₇

Products

产品目录编号包装 数量 / 包装
235427-1MGCN 玻璃瓶 1 mg
Description
Catalogue Number235427
Brand Family Calbiochem®
SynonymsCell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
References
ReferencesLin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Tewari, M., et al. 1995. Cell 81, 801.
Lazebnik, Y.A., et al. 1994. Nature 371, 346.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
Hill FormulaC₉₄H₁₅₈N₂₀O₂₇
Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
Hygroscopic Hygroscopic
ReversibleY
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-3
Primary Target IC<sub>50</sub>200 pM inhibiting PARP cleavage in cultured human osteosarcoma cell extracts
Purity≥90% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/38

Irritating to eyes and skin.
S PhraseS: 26

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
235427-1MGCN 04055977217056

Documentation

InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

InSolution™ Caspase-3 Inhibitor I, Cell-Permeable - Calbiochem 分析证书

标题批号
235427

参考

参考信息概述
Lin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
Nicholson, D.W., et al. 1995. Nature 376, 37.
Tewari, M., et al. 1995. Cell 81, 801.
Lazebnik, Y.A., et al. 1994. Nature 371, 346.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题
  • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision18-March-2008 JSW
    SynonymsCell-permeable, DEVD-CHO; CPP32/Apopain Inhibitor, Cell-permeable
    DescriptionA cell-permeable inhibitor of caspase-3. The C-terminal DEVD-CHO sequence of this peptide is a highly specific, potent, and reversible inhibitor of caspase-3 (Ki <1 nM) that has also been shown to strongly inhibit PARP cleavage in cultured human osteosarcoma cell extracts (IC50 = 200 pM). The N-terminal sequence (residues 1-16) corresponds to the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF) and confers cell-permeability to the peptide.
    FormLiquid
    FormulationA 5 mM (1 mg/100 µl) solution of Caspase-3 Inhibitor I, Cell-permeable (Cat. No. 235423) in DMSO.
    Intert gas (Yes/No) Packaged under inert gas
    Chemical formulaC₉₄H₁₅₈N₂₀O₂₇
    Peptide SequenceAc-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Glu-Val-Asp-CHO
    Purity≥90% by HPLC
    Storage Protect from light
    -20°C
    Hygroscopic
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing initial thaw, aliquot, purge with inert gas, and freeze (-20°C).
    Toxicity Irritant
    ReferencesLin, Y.-Z., et al. 1996. J. Biol. Chem. 271, 5305.
    Nicholson, D.W. 1996. Nature Biotechnol. 14, 297.
    Schlegel, J., et al. 1996. J. Biol. Chem. 271, 1841.
    Lin, Y.-Z., et al. 1995. J. Biol. Chem. 270, 14255.
    Nicholson, D.W., et al. 1995. Nature 376, 37.
    Tewari, M., et al. 1995. Cell 81, 801.
    Lazebnik, Y.A., et al. 1994. Nature 371, 346.
    Citation
  • Jurg Grunenfelder, et al. (2001) Upregulation of Bcl-2 through caspase-3 inhibition ameliorates ischemia/reperfusion injury in rat cardiac allografts. Circulation 104, I202-I206.
    		•