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218705 Sigma-AldrichInSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem

The InSolution™ Casein Kinase I Inhibitor, D4476 controls the biological activity of Casein Kinase I. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

Primary Target: CK1, CK1d

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₂₃H₁₈N₄O₃

Products

产品目录编号	包装	数量 / 包装
218705-1MGCN	塑胶安瓿;塑胶针药瓶	1 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Catalogue Number	218705
Brand Family	Calbiochem®

References
References	Rena, G., et al. 2004. EMBO Reports 5, 60.

Product Information
ATP Competitive	Y
Form	Liquid
Formulation	A 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
Hill Formula	C₂₃H₁₈N₄O₃
Chemical formula	C₂₃H₁₈N₄O₃
Hygroscopic	Hygroscopic
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	CK1, CK1d
Primary Target IC<sub>50</sub>	0.2 µM, 0.3 µM against CK1, CK1d, respectively
Purity	≥95% by HPLC
Concentration Label	Please refer to vial label for lot-specific concentration

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Shipped with Blue Ice or with Dry Ice
Toxicity	Irritant
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
218705-1MGCN	04055977202540

Documentation

InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

InSolution™ Casein Kinase I Inhibitor, D4476 - Calbiochem 分析证书

标题	批号
218705	输入批号

参考

参考信息概述
Rena, G., et al. 2004. EMBO Reports 5, 60.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	10-August-2023 JSW
Description	A cell-permeable, potent, and relatively specific ATP-competitive inhibitor of CK1 (IC₅₀ = 200 nM from S. pombe; 0.3 µM for CK1δ) and ALK5 (IC₅₀ = 500 nM). A weak inhibitor of p38α MAP kinase (IC₅₀ = 12 µM) and several other kinases tested, including PKB, SGK, and GSK-3β. Suppresses the site-specific phosphorylation (Ser³²² and Ser³²⁵) and nuclear exclusion of FOXO1A in H4IIE hepatoma cells. Shown to be ~10-fold more potent than IC261 (Cat. No. 400090; IC₅₀ = 2.5 µM for CK1).
Form	Liquid
Formulation	A 10 mM (1 mg/251 µl) solution of Casein Kinase I Inhibitor, D4476 (Cat. No. 218696) in DMSO
Intert gas (Yes/No)	Packaged under inert gas
Concentration Label	Please refer to vial label for lot-specific concentration
Chemical formula	C₂₃H₁₈N₄O₃
Structure formula
Purity	≥95% by HPLC
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following initial use, aliquot and refrigerate (4°C).
Toxicity	Irritant
References	Rena, G., et al. 2004. EMBO Reports 5, 60.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Casein Kinase (CK) Inhibitors

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