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124017 InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem

InSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a 10 mM solution in DMSO. A cell-permeable, reversible, selective inhibitor of Akt1 & Akt2 (IC50 = 58 nM & 210 nM).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: Akt1, Akt2, Akt3
124017
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概述

Replacement Information

重要规格表

Empirical Formula
C₃₄H₂₉N₇O

Products

产品目录编号包装 数量 / 包装
124017-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
Catalogue Number124017
Brand Family Calbiochem®
References
ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.
Product Information
ATP CompetitiveN
FormLiquid
FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
Hill FormulaC₃₄H₂₉N₇O
Chemical formulaC₃₄H₂₉N₇O
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationInSolution Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2, CAS 612847-09-3, is a 10 mM solution in DMSO. A cell-permeable, reversible, selective inhibitor of Akt1 & Akt2 (IC50 = 58 nM & 210 nM).
Biological Information
Primary TargetAkt1, Akt2, Akt3
Primary Target IC<sub>50</sub>58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays
Purity≥95% by HPLC
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Irritant
Storage ≤ -70°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
124017-1MGCN 07790788047993

Documentation

InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

InSolution™ Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 - Calbiochem 分析证书

标题批号
124017

参考

参考信息概述
Barnett, S.F., et al. 2005. Biochem. J. 385, 399.
DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.

小册子

标题
Akt
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-August-2011 RFH
DescriptionA cell-permeable, potent, and selective inhibitor of Akt1/Akt2 activity (IC50 = 58 nM, 210 nM, and 2.12 µM for Akt1, Akt2, and Akt3, respectively, in in vitro kinase assays). The inhibition is reported to be pleckstrin homology (PH) domain-dependent. It does not exhibit any inhibitory effect against PH domain-lacking Akts, or other closely related AGC family kinases, PKA, PKC, and SGK, even at concentrations as high as 50 µM. Overcomes Akt1/Akt2-mediated resistance to chemotherapeutics in tumor cells and is shown to block basal and stimulated phosphorylation/activation of Akt1/Akt2 both in cultured cells in vitro and in mice in vivo.
FormLiquid
FormulationA 10 mM (1 mg/181 µl) solution of Akt Inhibitor VIII, Isozyme-Selective, Akti-1/2 (Cat. No. 124018) in DMSO.
Intert gas (Yes/No) Packaged under inert gas
Concentration Label Please refer to vial label for lot-specific concentration
Chemical formulaC₃₄H₂₉N₇O
Structure formulaStructure formula
Purity≥95% by HPLC
Storage Protect from light
≤ -70°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Irritant
ReferencesBarnett, S.F., et al. 2005. Biochem. J. 385, 399.
DeFeo-Jones, D., et al. 2005. Mol. Cancer Ther. 4, 271.
Zhao, Z., et al. 2005. Bioorg. Med. Chem. Lett. 15, 905.
Lindsley, C.W., et al. 2005. Bioorg. Med. Chem. Lett. 15, 761.