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171264 InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem

171264
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
866405-64-3C₂₄H₂₅N₅O

Products

产品目录编号包装 数量 / 包装
171264-2MGCN 玻璃瓶 2 mg
Description
OverviewA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice. The solid form of this compound (Cat. No. 171260) is also available.
Catalogue Number171264
Brand Family Calbiochem®
Synonyms6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I
References
ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
Inoki, K., et al. 2003. Cell 115, 577.
Fryer, L.G., 2002. FEBS Lett. 531, 189.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.
Product Information
CAS number866405-64-3
FormLiquid
FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
Hill FormulaC₂₄H₂₅N₅O
Chemical formulaC₂₄H₂₅N₅O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
171264-2MGCN 04055977207200

Documentation

InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

InSolution™ AMPK Inhibitor, Compound C•2HCl - CAS 866405-64-3 - Calbiochem 分析证书

标题批号
171264

参考

参考信息概述
Yu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
Inoki, K., et al. 2003. Cell 115, 577.
Fryer, L.G., 2002. FEBS Lett. 531, 189.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.

小册子

标题
New Products: Volume 3, 2012
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2012 JSW
Synonyms6-(4-(2-Piperidin-1-yl-ethoxy)-phenyl)-3-pyridin-4-ylpyrazolo[1,5-a]pyrimidine, 2HCl, H₂O, Compound C, 2HCl, H₂O, AMPK Inhibitor I
DescriptionA cell-permeable pyrrazolopyrimidine compound that acts as a potent, selective, reversible, and ATP-competitive inhibitor of AMPK (AMP-activated protein kinase; Ki = 109 nM in the presence of 5 µM ATP and the absence of AMP). Does not affect the activities of ZAPK, Syk, PKCθ, PKA, or JAK3. Blocks celluar activities induced by AICAr (Cat. No. 123040) or Metformin (Cat. No. 317240). Induces weight loss by attenuating AMPK-mediated food intake in mice.
FormLiquid
FormulationA 10 mM (2 mg/408 µl) solution of AMPK Inhibitor, Compound C, 2HCl, (Cat. No. 171260) in H₂O.
Intert gas (Yes/No) Packaged under inert gas
CAS number866405-64-3
Chemical formulaC₂₄H₂₅N₅O
Structure formulaStructure formula
Purity≥98% by HPLC
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing intial thaw, aliquot and freeze (-20°C).
ReferencesYu, P.B., et al. 2008. Nat. Chem. Biol 4, 33.
Kim, E.K., et al. 2004. J. Biol. Chem. 279, 19970.
Lee, M., et al. 2003. J. Biol. Chem. 278, 39653.
Inoki, K., et al. 2003. Cell 115, 577.
Fryer, L.G., 2002. FEBS Lett. 531, 189.
Zhou, G., et al. 2001. J. Clin. Invest. 108, 1167.