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401477 Sigma-AldrichIκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem

The IκB Kinase Inhibitor Peptide, Cell-Permeable controls the biological activity of IκB Kinase. This small molecule/inhibitor is primarily used for Inflammation/Immunology applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂

Primary Target: LPS-induced IκB degradation by IKK in RAW 264.7 cells

Recommended Products

概述

Replacement Information

重要规格表

Empirical Formula
C₁₃₈H₂₂₉N₃₇O₄₅S

Products

产品目录编号	包装	数量 / 包装
401477-1MGCN	塑胶安瓿;塑胶针药瓶	1 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence fused to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells (< 50 µg/ml) and prevents NF-κB activation. Supplied as a trifluoroacetate salt.
Catalogue Number	401477
Brand Family	Calbiochem®
Synonyms	Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂

References
References	Swaroop, N., et al. 2001. Pharm. Res. 18, 1631. Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.

Product Information
ATP Competitive	N
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Hill Formula	C₁₃₈H₂₂₉N₃₇O₄₅S
Chemical formula	C₁₃₈H₂₂₉N₃₇O₄₅S
Hygroscopic	Hygroscopic
Reversible	N
Quality Level	MQ100

Applications

Biological Information
Primary Target	LPS-induced IκB degradation by IKK in RAW 264.7 cells
Primary Target IC<sub>50</sub>	<50 µg/ml for inhibiting LPS-induced IκB degradation by IκB kinases (IKK) in RAW 264.7 cells and prevents NF-κB activation
Purity	≥95% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Sequence	Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Blue Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Hygroscopic	Hygroscopic
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
401477-1MGCN	04055977211924

Documentation

IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

IκB Kinase Inhibitor Peptide, Cell-Permeable - Calbiochem 分析证书

标题	批号
401477	输入批号

参考

参考信息概述
Swaroop, N., et al. 2001. Pharm. Res. 18, 1631. Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	13-September-2007 RFH
Synonyms	Ac-AAVALLPAVLLALLAPDDRHDSGLDSMKDE-NH₂
Description	A 14-amino acid peptide corresponding to the active IκB phosphorylation recognition sequence, linked to the hydrophobic region of the fibroblast growth factor signal peptide to aid in cellular delivery. Specifically inhibits LPS-induced IκB degradation by IkB kinases (IKK) in RAW 264.7 cells (<50 μg/ml) and prevents NF-κB activation.
Form	Lyophilized
Formulation	Supplied as a trifluoroacetate salt.
Intert gas (Yes/No)	Packaged under inert gas
Chemical formula	C₁₃₈H₂₂₉N₃₇O₄₅S
Peptide Sequence	Ac-Ala-Ala-Val-Ala-Leu-Leu-Pro-Ala-Val-Leu-Leu-Ala-Leu-Leu-Ala-Pro-Asp-Asp-Arg-His-Asp-Ser-Gly-Leu-Asp-Ser-Met-Lys-Asp-Glu-NH₂
Purity	≥95% by HPLC
Solubility	PBS, pH 7.4 (1 mg/ml)
Storage	Protect from light -20°C Hygroscopic
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Swaroop, N., et al. 2001. Pharm. Res. 18, 1631. Traenckner, E.B., et al. 1995. EMBO. J. 14, 2876.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > NF-κB Activation

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