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382148 Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem

The Histone Deacetylase Inhibitor II, also referenced under CAS 174664-65-4, controls the biological activity of Histone Deacetylase. This small molecule/inhibitor is primarily used for Cell Structure applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: CBHA, m-Carboxycinnamic Acid bis-Hydroxamide

Primary Target: HDAC
382148
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
174664-65-4C₁₀H₁₀N₂O₄

Products

产品目录编号包装 数量 / 包装
382148-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma.
Catalogue Number382148
Brand Family Calbiochem®
SynonymsCBHA, m-Carboxycinnamic Acid bis-Hydroxamide
References
ReferencesCoffey, D.C., et al. 2001. Cancer Res. 61, 3591.
Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
Glick, R.D., et al. 1999. Cancer Res. 59, 4392.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.
Product Information
CAS number174664-65-4
ATP CompetitiveN
DeclarationNot available for sale in the United States.
FormOff-white solid
Hill FormulaC₁₀H₁₀N₂O₄
Chemical formulaC₁₀H₁₀N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHDAC
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
382148-5MGCN 04055977213157

Documentation

Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Histone Deacetylase Inhibitor II - CAS 174664-65-4 - Calbiochem 分析证书

标题批号
382148

参考

参考信息概述
Coffey, D.C., et al. 2001. Cancer Res. 61, 3591.
Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
Glick, R.D., et al. 1999. Cancer Res. 59, 4392.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.

技术信息

标题
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsCBHA, m-Carboxycinnamic Acid bis-Hydroxamide
DescriptionA cell-permeable second generation hybrid polar agent that acts as a histone deacetylase (HDAC) inhibitor. The HDAC inhibition is believed to arise as a result of the binding of the hydroxamic moiety to the active site zinc. Shown to be a potent inducer of transformed cell growth arrest and terminal differentiation (~4 µM). Induces apoptosis and the CD95/CD95-Ligand expression in human neuroblastoma cells, which can be blocked by Caspase Inhibitor Z-VAD-FMK (Cat. No. 627610).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number174664-65-4
Chemical formulaC₁₀H₁₀N₂O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCoffey, D.C., et al. 2001. Cancer Res. 61, 3591.
Coffey, D.C., et al. 2000. Pediatr. Oncol. 35, 577.
Marks, P.A., et al. 2000. J. Natl. Cancer Inst. 92, 1210.
Glick, R.D., et al. 1999. Cancer Res. 59, 4392.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 5705.