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373400 Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem

The Hh/Gli Antagonist, GANT58, also referenced under CAS 64048-12-0, controls the biological activity of Hh/Gli. This small molecule/inhibitor is primarily used for Cell Signaling applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503

373400
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
64048-12-0C₂₄H₁₆N₄S

Products

产品目录编号包装 数量 / 包装
373400-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~ 5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
Catalogue Number373400
Brand Family Calbiochem®
Synonyms4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
References
ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
Product Information
CAS number64048-12-0
FormYellow solid
Hill FormulaC₂₄H₁₆N₄S
Chemical formulaC₂₄H₁₆N₄S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
373400-5MGCN 04055977191110

Documentation

Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Hh/Gli Antagonist, GANT58 - CAS 64048-12-0 - Calbiochem 分析证书

标题批号
373400

参考

参考信息概述
Lauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
Synonyms4-(2,4,5-Tri(pyridin-4-yl)thiophen-3-yl)pyridine, NSC 75503
DescriptionA cell-permeable tetrapyridinylthiophene compound that acts as downstream Hedgehog (Hh) pathway blocker and targets Gli-mediated gene transactivation (IC50 ~5 µM in SAG-stimulated Shh-L2 cells). Its action appears to be Hh pathway-selective, downstream of Smo and Sufu, but does not seem to interfere with Gli DNA binding. Shown to reduce cellular mRNA levels of Hh target genes, Gli1, Hip1,& Ptch, and inhibit Gli-dependent tumor growth both in vitro and in vivo.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number64048-12-0
Chemical formulaC₂₄H₁₆N₄S
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Regulatory Review
ReferencesLauth, M., et al. 2007. Proc. Natl. Acad. Sci. USA 104, 8455.