352010 Sigma-AldrichGlutaminase Inhibitor, Compound 968 - CAS 311795-38-7 - Calbiochem
Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells.
More>> Glutaminase Inhibitor, Compd 968, is a cell-permeable, reversible inhibitor of mitochondrial glutaminase. Represses growth & invasive activity in glutaminase upregulated fibroblasts and tumor cells. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: GAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 311795-38-7 | C₂₇H₂₇BrN₂O |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
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| 352010-10MGCN | 玻璃瓶 | 10 mg |
| Description | |
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| Overview | A cell-permeable benzophenanthridinone compound that acts as an allosteric and reversible inhibitor of mitochondrial glutaminase activity and represses the growth and invasive activity in glutaminase upregulated fibroblasts and in tumor cells (IC50 ≤ 10 µM in NIH3T3 cells stably expressing Dbl, Cdc42-F28L, Rac-F28L or RhoC-F30L mutants and in SKBR3 and MDA-MB231 cancer cells). Shown to effectively shrink tumor size in P-493 B xenografted mouse model (200 µg per inj. i.p., 12 days). Also available as a 10 mM solution in DMSO (Cat. No. 506073). |
| Catalogue Number | 352010 |
| Brand Family | Calbiochem® |
| Synonyms | GAC Inhibitor, GLS1 Inhibitor I, KGA Inhibitor I, Kidney-Type Glutaminase Inhibitor I, 5-(3-Bromo-4-(dimethylamino)phenyl)-2,2-dimethyl-2,3,5,6-tetrahydrobenzo[a]phenanthridin-4(1H)-one |
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| References | Wang, J.B., et al. 2010. Cancer Cell 18, 207. |
| Product Information | |
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| CAS number | 311795-38-7 |
| Form | White powder |
| Hill Formula | C₂₇H₂₇BrN₂O |
| Chemical formula | C₂₇H₂₇BrN₂O |
| Quality Level | MQ100 |
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| Purity | ≥99% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 352010-10MGCN | 04055977193237 |
Documentation
Glutaminase Inhibitor, Compound 968 - CAS 311795-38-7 - Calbiochem MSDS
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Glutaminase Inhibitor, Compound 968 - CAS 311795-38-7 - Calbiochem 分析证书
| 标题 | 批号 |
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| 352010 |
参考
| 参考信息概述 |
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| Wang, J.B., et al. 2010. Cancer Cell 18, 207. |