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346007 Glucagon-Like Peptide 1 Receptor Agonist II - CAS 1371569-69-5 - Calbiochem

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine , Glucagon-Like Peptide 1 Receptor Agonist II, Compound B

346007
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
1371569-69-5C₂₀H₁₇F₃N₂O₂S

Products

产品目录编号包装 数量 / 包装
346007-10MGCN 玻璃瓶 10 mg
Description
OverviewA pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50 = 0.66 µM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo, this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo, at concentrations between 1 and 10 µM.
Catalogue Number346007
Brand Family Calbiochem®
Synonyms4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine , Glucagon-Like Peptide 1 Receptor Agonist II, Compound B
References
ReferencesSloop, KW., et al. 2010. Diabetes. 59, 3099.
Product Information
CAS number1371569-69-5
FormOff-white solid
Hill FormulaC₂₀H₁₇F₃N₂O₂S
Chemical formulaC₂₀H₁₇F₃N₂O₂S
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity>95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
346007-10MGCN 04055977214611

Documentation

Glucagon-Like Peptide 1 Receptor Agonist II - CAS 1371569-69-5 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Glucagon-Like Peptide 1 Receptor Agonist II - CAS 1371569-69-5 - Calbiochem 分析证书

标题批号
346007

参考

参考信息概述
Sloop, KW., et al. 2010. Diabetes. 59, 3099.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
Synonyms4-(3-(benzyloxy)phenyl)-2-(ethylsulfinyl)-6-(trifluoromethyl)pyrimidine , Glucagon-Like Peptide 1 Receptor Agonist II, Compound B
DescriptionA pyrimidine small molecule that acts as a GLP-1 allosteric agonist that induces cAMP signaling in HEK293 cells expressing the GLP-1 receptor with EC50 = 0.66 µM and 99% efficacy (similar data with rat GLP-1 receptor), does not compete with radiolabelled GLP-1 in receptor binding assays, and is not active in cells expressing the GLP-2, GIP, PTH, or glucagon receptors. In rodent islets, insulin secretion increases in a dose-dependent and glucose-dependent manner, either alone or in an additive fashion when combined with the endogenous GLP-1 peptide. In vivo, this molecule exhibits insulinotropic effects when dosed at 10mg/kg in SD rats undergoing an IVGTT and a hyperglycemic clamp. It is also shown to increase insulin secretion in perifusion assays involving normal and diabetic human islets ex vivo, at concentrations between 1 and 10 µM.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1371569-69-5
Chemical formulaC₂₀H₁₇F₃N₂O₂S
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSloop, KW., et al. 2010. Diabetes. 59, 3099.