342500 Sigma-AldrichFK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem
Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2.
More>> Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: Tacrolimus
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概述
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重要规格表
| CAS # | Empirical Formula |
|---|---|
| 104987-11-3 | C₄₄H₆₉NO₁₂ |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 342500-5MGCN | 塑胶安瓿;塑胶针药瓶 | 5 mg |
| Description | |
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| Overview | Immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca2+ release. Inhibits the Ca2+-dependent phosphatase, Protein Phosphatase 2B (Calcineurin; Cat. No. 539568), as well as Na+,K+-ATPase in nephron segments. Also shown to inhibit aldosterone-induced synthesis of Giα-3 protein. |
| Catalogue Number | 342500 |
| Brand Family | Calbiochem® |
| Synonyms | Tacrolimus |
| Product Information | |
|---|---|
| CAS number | 104987-11-3 |
| ATP Competitive | N |
| Form | Off-white solid |
| Hill Formula | C₄₄H₆₉NO₁₂ |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
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| Biological Information | |
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| Primary Target | Immunosuppressant that blocks T cell proliferation |
| Purity | ≥98% by TLC |
| Physicochemical Information | |
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| Cell permeable | N |
| Dimensions |
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| Materials Information |
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| Toxicological Information |
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| Safety Information according to GHS | |
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| RTECS | KD4200000 |
| Product Usage Statements |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 342500-5MGCN | 04055977195002 |
Documentation
FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem MSDS
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FK-506, Streptomyces sp. - CAS 104987-11-3 - Calbiochem 分析证书
| 标题 | 批号 |
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| 342500 |
参考
| 参考信息概述 |
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| Asano, K., et al. 1996. In Vivo 10, 537. McCall, E., et al. 1996. Circ. Res. 79, 1110. Raufman, J.P., et al. 1996. J. Biol. Chem. 271, 19877. Rokaw, M.D., et al. 1996. Am. J. Physiol. 271, C194. |