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05-23-3800 Sigma-AldrichEndothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem

Endothelin 1, Human and Porcine, CAS 117399-94-7, is a 21-amino acid polypeptide with potent vasoconstrictive action. Activates phospholipase C in fibroblasts expressing ETA receptors.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: ET-1, CSCSSLMDKECVYFCHLDIIW

Primary Target: Potent vasoconstrictive action

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
117399-94-7	C₁₀₉H₁₅₉N₂₅O₃₂S₅

Products

产品目录编号	包装	数量 / 包装
05-23-3800-0.1MGCN	塑胶安瓿;塑胶针药瓶	.1 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹
05-23-3800-0.5MGCN	塑胶安瓿;塑胶针药瓶	.5 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹
05-23-3800-1MGCN	塑胶安瓿;塑胶针药瓶	1 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A 21-amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca²⁺ channels. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.
Catalogue Number	05-23-3800
Brand Family	Calbiochem®
Synonyms	ET-1, CSCSSLMDKECVYFCHLDIIW

References
References	Cesari, M., et al. 1996. Am. Heart J. 132, 1236. Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169. Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524. Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294. Itoh, Y., et al. 1988. FEBS Lett. 231, 440. Yanagisawa, M., et al. 1988. Nature 332, 411.

Product Information
CAS number	117399-94-7
ATP Competitive	N
Form	White to off-white solid
Formulation	Supplied as an acetate salt.
Hill Formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Chemical formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Reversible	N
Sold on the basis of peptide content	Y
Quality Level	MQ100

Applications

Biological Information
Primary Target	Potent vasoconstrictive action
Purity	≥96% by HPLC

Physicochemical Information
Cell permeable	N
Peptide Content	Y
Peptide Sequence	H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Moisture	Protect from moisture
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.

Packaging Information

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
05-23-3800-0.1MGCN	04055977226775
05-23-3800-0.5MGCN	04055977226782
05-23-3800-1MGCN	04055977226799

Documentation

Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Endothelin 1, Human and Porcine - CAS 117399-94-7 - Calbiochem 分析证书

标题	批号
05-23-3800	输入批号

参考

参考信息概述
Cesari, M., et al. 1996. Am. Heart J. 132, 1236. Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169. Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524. Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294. Itoh, Y., et al. 1988. FEBS Lett. 231, 440. Yanagisawa, M., et al. 1988. Nature 332, 411.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	12-May-2008 JSW
Synonyms	ET-1, CSCSSLMDKECVYFCHLDIIW
Description	A 21 amino acid polypeptide with potent vasoconstrictive action. Produces convulsions, arterial hypertension, and metabolic activation of periventricular white and gray matter. Its effects are mediated via L-type Ca²⁺ channels. Reported to activate phospholipase C in fibroblasts expressing ET_A receptors.
Form	White to off-white solid
Formulation	Supplied as an acetate salt.
CAS number	117399-94-7
Chemical formula	C₁₀₉H₁₅₉N₂₅O₃₂S₅
Peptide Sequence	H-Cys¹-Ser-Cys³-Ser-Ser-Leu-Met-Asp-Lys-Glu-Cys¹¹-Val-Tyr-Phe-Cys¹⁵-His-Leu-Asp-Ile-Ile-Trp-OH (disulfide bonds: 1 → 15; 3 → 11)
Purity	≥96% by HPLC
Solubility	5% Acetic acid (0.5 mg/ml). Dissolve peptide initially at 8 mg/ml in 80% cold acetic acid, then dilute with distilled water to achieve 5% acetic acid and 0.5 mg/ml peptide.
Storage	Protect from moisture -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 weeks at -20°C.
Toxicity	Standard Handling
References	Cesari, M., et al. 1996. Am. Heart J. 132, 1236. Gresser, O., et al 1996. Biochem. Biophys. Res. Commun. 224, 169. Murata, S., et al. 1995. J. Pharmacol. Exp. Ther. 274, 1524. Hexum, T.D., et al. 1990. Biochem. Biophys. Res. Commun. 167, 294. Itoh, Y., et al. 1988. FEBS Lett. 231, 440. Yanagisawa, M., et al. 1988. Nature 332, 411.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Neurochemicals > Agonists > Endothelin Receptor Agonists

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