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			96-Well Plate

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	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

324875 Sigma-AldrichEicosapentaenoic Acid - CAS 10417-94-4 - Calbiochem

Cell permeable. Shown to have a beneficial effect in cardiovascular diseases and inflammation. Inhibits 5-lipoxygenase and reduces thromboxane A₂ production and blood viscosity.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

分析证书
参考
Data Sheet

同义词: EPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3

Primary Target: 5-lipoxygenase

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
10417-94-4	C₂₀H₃₀O₂

Products

产品目录编号	包装	数量 / 包装
324875-25MGCN	玻璃瓶	25 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	Cell permeable. Shown to have a beneficial effect in cardiovascular diseases and inflammation. Causes elevation of intracellular free Ca²⁺. Inhibits 5-lipoxygenase and reduces thromboxane A₂ production and blood viscosity. Reported to induce apoptosis in pancreatic cancer cell lines and to inhibit liver metastasis.
Catalogue Number	324875
Brand Family	Calbiochem®
Synonyms	EPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3

References
References	Iwamoto, S., et al. 1998. Nutr. Cancer 31, 143. Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375. Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830. Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166. James, M.J., et al. 1993. J. Exp. Med. 178, 2261. chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19. Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.

References

Iwamoto, S., et al. 1998. Nutr. Cancer 31, 143.
Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375.
Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830.
Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166.
James, M.J., et al. 1993. J. Exp. Med. 178, 2261.
chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19.
Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.

Product Information
CAS number	10417-94-4
ATP Competitive	N
Form	Clear liquid
Hill Formula	C₂₀H₃₀O₂
Chemical formula	C₂₀H₃₀O₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	5-lipoxygenase
Purity	≥99% by GC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS
RTECS	JX3820000

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Dry Ice Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
324875-25MGCN	04055977215847

Documentation

Eicosapentaenoic Acid - CAS 10417-94-4 - Calbiochem 分析证书

标题	批号
324875	输入批号

参考

参考信息概述
Iwamoto, S., et al. 1998. Nutr. Cancer 31, 143. Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375. Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830. Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166. James, M.J., et al. 1993. J. Exp. Med. 178, 2261. chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19. Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	02-May-2008 RFH
Synonyms	EPA, 5,8,11,14,17-Eicosapentaenoic Acid, C20:5 ω-3
Description	Fatty acid isolated from microscopic algae. Serves as a precursor for the prostaglandin-3 and thromboxane-3 families. It differs from arachidonic acid by the extra double bond between C₁₇ and C₁₈. Has a beneficial effect in cardiovascular diseases and inflammation. Also acts as an antihyperlipoproteinenic agent. Causes elevations of intracellular free Ca²⁺. Inhibits 5-lipoxygenase and reduces thromboxane A2 production and blood viscosity.
Form	Clear liquid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	10417-94-4
RTECS	JX3820000
Chemical formula	C₂₀H₃₀O₂
Structure formula
Purity	≥99% by GC
Solubility	Methanol (1 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following initial thaw, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity	Standard Handling
Merck USA index	14, 3531
References	Iwamoto, S., et al. 1998. Nutr. Cancer 31, 143. Lai, P.B., et al. 1996. Br. J. Cancer 74, 1375. Marotta, F., et al. 1995. Digestion 56, 46. Kurihara, T., et al. 1994. Clin. Ther. 16, 830. Okuda, Y., et al. 1994. Biochem. Med. Metab. Biol. 51, 166. James, M.J., et al. 1993. J. Exp. Med. 178, 2261. chamcock, J.S., et al. 1992. Mol. Cell. Biochem. 116, 19. Stenson, W.F., et al. 1992. Ann. Intern. Med. 116, 609.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Lipid Signaling Inhibitors > Lipoxygenase (LOX) Inhibitors

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