Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

324483 Ebselen - CAS 60940-34-3 - Calbiochem

A cell-permeable, non-selective inhibitor of COX-1 and COX-2.

Ebselen - CAS 60940-34-3 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51

Primary Target: COX-1, COX-2
324483
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
60940-34-3C₁₃H₉NOSe

Products

产品目录编号包装 数量 / 包装
324483-5MGCN 玻璃瓶 5 mg
Description
OverviewA cell-permeable, non-selective inhibitor of COX-1 and COX-2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent active against acute focal ischemic injury. Inhibits LPS-induced NF-κB nuclear translocation and LPS-induced phosphorylation of JNK.
Catalogue Number324483
Brand Family Calbiochem®
Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
References
ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.
Product Information
CAS number60940-34-3
ATP CompetitiveN
FormLyophilized solid
Hill FormulaC₁₃H₉NOSe
Chemical formulaC₁₃H₉NOSe
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1, COX-2
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
324483-5MGCN 04055977197242

Documentation

Ebselen - CAS 60940-34-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Ebselen - CAS 60940-34-3 - Calbiochem 分析证书

标题批号
324483

参考

参考信息概述
Shimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.

小册子

标题
Alzheimer's Disease Brochure & Technical Guide
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2008 RFH
Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
DescriptionNon-selective, cell-permeable, inhibitor of the cyclooxygenase activity of prostaglandin H synthase 1 and 2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent against acute focal ischemic injury.
FormLyophilized solid
CAS number60940-34-3
Chemical formulaC₁₃H₉NOSe
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (5 mg/ml) or Ethanol
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.