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324890 E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem

E-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: (2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide

Primary Target: cysteine proteases
324890
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
66701-25-5C₁₅H₂₇N₅O₅

Products

产品目录编号包装 数量 / 包装
324890-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
324890-25MGCN 玻璃瓶 25 mg
324890-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewIrreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
Catalogue Number324890
Brand Family Calbiochem®
Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
References
ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J. 201, 189.
Product Information
CAS number66701-25-5
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₂₇N₅O₅
Chemical formulaC₁₅H₂₇N₅O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
ApplicationE-64 Protease Inhibitor, CAS 66701-25-5, is an irreversible inhibitor of cysteine proteases. Interacts with the Sn subsites of proteases. Has no action on cysteine residues in other proteins.
Biological Information
Primary Targetcysteine proteases
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSRR0390000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
324890-1MGCN 04055977196146
324890-25MGCN 04055977196160
324890-5MGCN 04055977196177

Documentation

E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

E-64 Protease Inhibitor - CAS 66701-25-5 - Calbiochem 分析证书

标题批号
324890

参考

参考信息概述
Matsumoto, K., et al. 1999. Biopolymers 51, 99.
Sarin, A., et al. 1994. J. Immunol. 153, 862.
Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
Barrett, A.J. 1982. Biochem. J. 201, 189.

引用

标题
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision12-July-2013 JSW
    Synonyms(2R,3R)-3-((S)-1-(4-Guanidinobutylamino)-4-methyl-1-oxopentan-2-ylcarbamoyl)oxirane-2-carboxylic acid, trans-Epoxysuccinyl-L-​leucylamido(4-​guanidino)​butane, L-trans-​3-​Carboxyoxiran-​2-​carbonyl-L-leucylagmatine, N-​(trans-​Epoxysuccinyl)​-L-leucine 4-​guanidinobutylamide
    DescriptionIrreversible inhibitor of cysteine proteases. Has no action on cysteine residues in other proteins. Inhibits activation-induced programmed cell death and restores defective immune responses in HIV+ donors. Specific active site titrant.
    FormWhite solid
    CAS number66701-25-5
    RTECSRR0390000
    Chemical formulaC₁₅H₂₇N₅O₅
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (25 mg/ml) or H₂O (20 mg/ml)
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.
    Toxicity Standard Handling
    ReferencesMatsumoto, K., et al. 1999. Biopolymers 51, 99.
    Sarin, A., et al. 1994. J. Immunol. 153, 862.
    Sarin, A., et al. 1993. J. Exp. Med. 178, 1693.
    Barrett, A.J. 1982. Biochem. J. 201, 189.
    Citation
  • Ok Hee Ryu, et al. (2005) Proteolysis of MIP-1α isoforms LD78β and LD78α by neutrophil-derived serine proteases. Journal of Biological Chemistry 280, 17415-17421.
    		•