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574215 Sigma-AldrichD,L-Sulforaphane - CAS 4478-93-7 - Calbiochem

D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane

Primary Target: Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
4478-93-7	C₆H₁₁NOS₂

Products

产品目录编号	包装	数量 / 包装
574215-25MGCN	塑胶安瓿;塑胶针药瓶	25 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. It has been shown to be an effective agent in prevention of chemically-induced mammary tumors in rats. It also inhibits the phase I cytochrome P450 isoenzymes 2E1 and IA2 which have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by mitogen-activated protein kinase (MAPK) pathway.
Catalogue Number	574215
Brand Family	Calbiochem®
Synonyms	1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane

References
References	Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426. Yu, R., et al. 2000. J. Biol. Chem. 275, 2322. Yu, R., et al. 1999. J. Biol. Chem. 274, 27545. Barcelo, S., et al. 1998. Mutat. Res. 402, 111. Maheo, K., et al. 1997. Cancer Res. 57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.

References

Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426.
Yu, R., et al. 2000. J. Biol. Chem. 275, 2322.
Yu, R., et al. 1999. J. Biol. Chem. 274, 27545.
Barcelo, S., et al. 1998. Mutat. Res. 402, 111.
Maheo, K., et al. 1997. Cancer Res. 57, 3649.
Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147.
Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.

Product Information
CAS number	4478-93-7
ATP Competitive	N
Form	Slight yellow liquid
Hill Formula	C₆H₁₁NOS₂
Chemical formula	C₆H₁₁NOS₂
Reversible	N
Structure formula Image
Quality Level	MQ100

Applications
Application	D,L-Sulforaphane, CAS 4478-93-7, is an anti-tumor agent that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture.

Biological Information
Primary Target	Potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture
Purity	≥98% by UPLC

Physicochemical Information
Cell permeable	N

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
574215-25MGCN	04055977189568

Documentation

D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

D,L-Sulforaphane - CAS 4478-93-7 - Calbiochem 分析证书

标题	批号
574215	输入批号

参考

参考信息概述
Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426. Yu, R., et al. 2000. J. Biol. Chem. 275, 2322. Yu, R., et al. 1999. J. Biol. Chem. 274, 27545. Barcelo, S., et al. 1998. Mutat. Res. 402, 111. Maheo, K., et al. 1997. Cancer Res. 57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.

参考信息概述

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	26-March-2008 JSW
Synonyms	1-Isothiocyanato-4-(methylsulfinyl)butane, R,S-Sulforaphane
Description	An isothiocyanate isolated from broccoli that acts as a potent inducer of phase II detoxifying enzymes in mouse tissues and murine hepatoma cells in culture. Shown to be an effective agent in prevention of chemically-induce mammary tumors in rats. Also shown to inhibit the phase I cytochrome P450 isoenzymes 2E1 and IA2 that have been associated with the activation of carcinogens. The induction of phase II enzymes is mediated by the mitogen-activated protein kinase (MAPK) pathway.
Form	Slight yellow liquid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	4478-93-7
Chemical formula	C₆H₁₁NOS₂
Structure formula
Purity	≥98% by UPLC
Solubility	DMSO (20 mg/ml) or ethanol (10 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze DMSO stock solutions (-20°C) and ethanol stock solutions (-70°C). DMSO stock solutions are stable for up to 3 months at -20°C and ethanol stock solutions are stable for up to 3 months at -70°C.
Toxicity	Standard Handling
References	Gamet-Payrastre, L., et al. 2000. Cancer Res. 60, 1426. Yu, R., et al. 2000. J. Biol. Chem. 275, 2322. Yu, R., et al. 1999. J. Biol. Chem. 274, 27545. Barcelo, S., et al. 1998. Mutat. Res. 402, 111. Maheo, K., et al. 1997. Cancer Res. 57, 3649. Zhang, Y., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 3147. Zhang, Y., et al. 1992. Proc. Natl. Acad. Sci. USA 89, 2399.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Anticancer Agents

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