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234200 Combretastatin A-4 - CAS 117048-59-6 - Calbiochem

A synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine tubulin binding and interferes with tubulin polymerization as well as cellular microtubule assembly

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: NSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII

234200
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
117048-59-6C₁₈H₂₀O₅

Products

产品目录编号包装 数量 / 包装
234200-10MGCN 10 mg
Description
OverviewA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
Catalogue Number234200
Brand Family Calbiochem®
SynonymsNSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII
References
ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
Pettit, G.R., et al. 1989. Experientia 45, 209.
Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
Product Information
CAS number117048-59-6
FormOff-white solid
Hill FormulaC₁₈H₂₀O₅
Chemical formulaC₁₈H₂₀O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
234200-10MGCN 04055977200126

Documentation

Combretastatin A-4 - CAS 117048-59-6 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Combretastatin A-4 - CAS 117048-59-6 - Calbiochem 分析证书

标题批号
234200

参考

参考信息概述
Tron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
Pettit, G.R., et al. 1989. Experientia 45, 209.
Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision26-April-2010 RFH
SynonymsNSC 817373, 2-Methoxy-5-((1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl)-phenol, CA-4, Combretastatin A4, CA4, Tubulin Polymerization Inhibitor XVIII
DescriptionA synthetic Combretum caffrum-derived cell-permeable stilbenoid phenol that competes with colchicine (Cat. No. 234115) tubulin binding (by 96.4% at equal molar concentration; Ki = 1.1 µM) and interferes with tubulin polymerization (IC50 = 2-3 µM) as well as cellular microtubule assembly. In addition to its antimitotic and in vitro cancer growth inhibition activity (IC50 = 7 nM in L1210 cultures), CA4 also acts as an antivascular agent and effectively induces tumor cell necrosis in vivo by targeting endothelial cytoskeleton.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number117048-59-6
Chemical formulaC₁₈H₂₀O₅
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesTron, G.C., et al. 2006. J. Med. Chem. 49, 3033.
Griggs, J., et al. 2001. Lancet Oncol. 2, 82.
Pettit, G.R., et al. 1989. Experientia 45, 209.
Lin, C.M., et al. 1988. Mol. Pharmacol. 34, 200.