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220285 Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem

Naturally-occurring alkaloid.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: PKC
220285
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
3895-92-9C₂₁H₁₈NO₄Cl

Products

产品目录编号包装 数量 / 包装
220285-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewNaturally-occurring alkaloid. Potent, selective, and cell-permeable inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain of PKC. A competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
Catalogue Number220285
Brand Family Calbiochem®
References
ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Barg, J., et al. 1992. J. Neurochem. 59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
Walterova, D., et al. J. Med. Chem. 24, 1100.
Product Information
CAS number3895-92-9
ATP CompetitiveN
FormLight yellow to yellow solid
Hill FormulaC₂₁H₁₈NO₄Cl
Chemical formulaC₂₁H₁₈NO₄Cl
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKC
Primary Target IC<sub>50</sub>660 nM
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSFL9200000
Safety Information
R PhraseR: 20/21/22-36/37/38

Harmful by inhalation, in contact with skin and if swallowed.
Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
220285-5MGCN 07790788048761

Documentation

Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Chelerythrine Chloride - CAS 3895-92-9 - Calbiochem 分析证书

标题批号
220285

参考

参考信息概述
Kandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Barg, J., et al. 1992. J. Neurochem. 59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
Walterova, D., et al. J. Med. Chem. 24, 1100.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision15-July-2022 JSW
DescriptionNaturally occurring alkaloid. Cell-permeable, selective inhibitor of protein kinase C (IC50 = 660 nM). Acts on the catalytic domain irrespective of the attachment of the regulatory domain. Material is a competitive inhibitor with respect to the phosphate acceptor and a non-competitive inhibitor with respect to ATP. Over ten-fold more potent than H-7, HCl (Cat. No. 371955). Inhibits thromboxane formation and phosphoinositide metabolism in platelets. Also induces apoptotic DNA fragmentation and cell death in HL-60 human promyelocytic leukemia cells.
FormLight yellow to yellow solid
CAS number3895-92-9
RTECSFL9200000
Chemical formulaC₂₁H₁₈NO₄Cl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml) or H₂O (1 mg/ml). Heating to 40-50°C with gentle agitation may be necessary to achieve complete solubilization. Further dilute with buffer just prior to use.
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Harmful
Merck USA index14, 2051
ReferencesKandasamy, R.A., et al. 1995. J. Biol. Chem. 270 29209.
Jarvis, W.D., et al. 1994. Cancer Res. 54, 1707.
Barg, J., et al. 1992. J. Neurochem. 59, 1145.
Herbert, J.M., et al. 1990. Biochem. Biophys. Res. Commun. 172, 993.
Ko, F., et al. 1990. Biochim. Biophys. Acta 1052, 360.
Walterova, D., et al. J. Med. Chem. 24, 1100.