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238811 Cdk9 Inhibitor II - CAS 140651-18-9 - Calbiochem

238811
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概述

重要规格表

CAS #Empirical Formula
140651-18-9C₉H₁₀N₆O

Products

产品目录编号包装 数量 / 包装
238811-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable azo-pyrazole compound that acts as a potent, ATP-competitive, and Cdk9-selective inhibitor (IC50 = 350 nM, using Cdk9/T1). It inhibits Cdk1/B, Cdk2/E, Cdk2/A, Cdk4/D1, Cdk7/H, and p70S6K only at much higher concentrations (IC50 = 44, 20, 69, 13.5, 26, and 10 µM, respectively) and shows little or no activity against eight other commonly studied kinases even at concentrations as high as 10 µM. Shown to exhibit antiproliferative activity in human tumor cell lines.
Catalogue Number238811
Brand Family Calbiochem®
Synonyms4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol
References
ReferencesKrystof, V., et al. 2006. J. Med. Chem. 49, 6500.
Product Information
CAS number140651-18-9
ATP CompetitiveY
FormOrange solid
Hill FormulaC₉H₁₀N₆O
Chemical formulaC₉H₁₀N₆O
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Biological Information
Primary TargetCdk9
Primary Target IC<sub>50</sub>350 nM, using Cdk9/T1
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Global Trade Item Number
产品目录编号 GTIN
238811-5MGCN 04055977216646