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219385 Cathepsin B Inhibitor II - Calbiochem

219385
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概述

Replacement Information

重要规格表

Empirical Formula
C₁₉H₃₆N₄O₄

Products

产品目录编号包装 数量 / 包装
219385-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA more active lysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) compared to leupeptin (IC50 = 310 nM).
Note: this peptide forms cyclic isomers.
Catalogue Number219385
Brand Family Calbiochem®
SynonymsAc-LVK-CHO
References
ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₉H₃₆N₄O₄
Chemical formulaC₁₉H₃₆N₄O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>4 nM against cathepsin B
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceAc-Leu-Val-lysinal
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage ≤ -70°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
219385-1MGCN 04055977201666

Documentation

Cathepsin B Inhibitor II - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Cathepsin B Inhibitor II - Calbiochem 分析证书

标题批号
219385

参考

参考信息概述
McConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.

小册子

标题
Cathepsins and Related Products Technical Bulletin

引用

标题
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.
  • 数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision03-October-2007 RFH
    SynonymsAc-LVK-CHO
    DescriptionLysinal analog of Leupeptin (Cat. No. 108975). A more potent inhibitor of cathepsin B (IC50 = 4 nM) than of leupeptin (IC50 = 310 nM). Note: this peptide forms cyclic isomers.
    FormWhite solid
    Chemical formulaC₁₉H₃₆N₄O₄
    Peptide SequenceAc-Leu-Val-lysinal
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityH₂O (1 mg/ml)
    Storage ≤ -70°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-70°C). Stock solutions are stable for up to 1 month at -70°C.
    Toxicity Standard Handling
    ReferencesMcConnell, R.M., et al. 1993. J. Med. Chem. 36, 1084.
    Citation
  • Moin U Fareed, et al. (2006) Treatment of rats with calpain inhibitors prevents sepsis-induced muscle proteolysis independent of atrogin-1/MAFbx and MuRF1 expression. American Journal of Physiology Regulatory, Integrative and Comparative Physiology 290, R1589-R1597.