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219362 Cathepsin B, Human Liver

Cathepsin B, Human Liver, CAS 9047-22-7, is a purified native cathepsin B from human liver, purified by affinity chromatography. Upregulated in many types of tumors.

Cathepsin B, Human Liver MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
219362
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概述

Replacement Information

Products

产品目录编号包装 数量 / 包装
219362-50UGCN 塑胶安瓿;塑胶针药瓶 50 μg
Description
OverviewNative cathepsin B from human liver, purified by affinity chromatography and HPLC. The most investigated enzyme of all lysosomal cysteine proteases. Upregulation and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their invasive and metastatic capabilities. Cathepsin B is shown to facilitate tumor invasion by dissolving extracellular barriers.
Catalogue Number219362
Brand Family Calbiochem®
References
ReferencesHirai, K., et al. 1999. Hum. Pathol. 30, 680.
Kostoulas, G., et al. 1999. FEBS Lett. 455, 286.
Strojnik, T., et al. 1999. Clin. Cancer Res. 5, 559.
Maquire, T.M., et al. 1998. Int. J. Biol. Markers 13, 139.
Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.
Product Information
CAS number9047-22-7
Unit of DefinitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-RR-β-naphthylamide per min at 40°C, using 100 mM Na<sup>+</sup>/K<sup>+</sup> pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.
EC number3.4.22.1
FormLiquid
FormulationIn 50 mM sodium acetate buffer, 1 mM EDTA, pH 5.0.
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by SDS-PAGE
SourcePrepared from tissues of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
Specific Activity≥10 units/mg protein
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
219362-50UGCN 04055977202205

Documentation

Cathepsin B, Human Liver MSDS

职位

物料安全数据表 (MSDS) 

Cathepsin B, Human Liver 分析证书

标题批号
219362

参考

参考信息概述
Hirai, K., et al. 1999. Hum. Pathol. 30, 680.
Kostoulas, G., et al. 1999. FEBS Lett. 455, 286.
Strojnik, T., et al. 1999. Clin. Cancer Res. 5, 559.
Maquire, T.M., et al. 1998. Int. J. Biol. Markers 13, 139.
Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.

小册子

标题
Cathepsins and Related Products Technical Bulletin
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-May-2010 JSW
DescriptionNative cathepsin B from human liver, purified by affinity chromatography and HPLC. The most investigated enzyme of all lysosomal cysteine proteases. Upregulation and secretion of cathepsin B have been shown to occur in many types of tumors and to correlate positively with their invasive and metastatic capabilities.
FormLiquid
FormulationIn 50 mM sodium acetate buffer, 1 mM EDTA, pH 5.0.
SourcePrepared from tissues of individuals that have been shown by certified tests to be negative for HBsAg and for antibodies to HIV and HCV.
CAS number9047-22-7
EC number3.4.22.1
Purity≥95% by SDS-PAGE
Specific activity≥10 units/mg protein
Unit definitionOne unit is defined as the amount of enzyme that will hydrolyze 1.0 µmol Z-RR-β-naphthylamide per min at 40°C, using 100 mM Na+/K+ pH 6.0, with 1.33 mM EDTA and 2 mM DTT as the activation buffer.
Storage Avoid freeze/thaw
≤ -70°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
Merck USA index14, 1905
ReferencesHirai, K., et al. 1999. Hum. Pathol. 30, 680.
Kostoulas, G., et al. 1999. FEBS Lett. 455, 286.
Strojnik, T., et al. 1999. Clin. Cancer Res. 5, 559.
Maquire, T.M., et al. 1998. Int. J. Biol. Markers 13, 139.
Berquim, I.M., and Sloane, B.F. 1996. Adv. Exp. Med. Biol. 389, 281.