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219007 Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem

Z-VAD-FMK, CAS 161401-82-7, is an irreversible pan caspase inhibitor. Does not require pretreatment with esterase for in vitro studies.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Z-VAD-FMK

Primary Target: general caspase inhibitor
219007
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
161401-82-7C₂₁H₂₈FN₃O₇

Products

产品目录编号包装 数量 / 包装
219007-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
219007-250UGCN 塑胶安瓿;塑胶针药瓶 250 μg
Description
OverviewAn irreversible general caspase inhibitor. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies. A 10 mM (1 mg/221 µl) solution of Caspase Inhibitor VI (Cat. No. 219011) in DMSO is also available.
Catalogue Number219007
Brand Family Calbiochem®
SynonymsZ-VAD-FMK
References
ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
Product Information
CAS number161401-82-7
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₂₁H₂₈FN₃O₇
Chemical formulaC₂₁H₂₈FN₃O₇
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetgeneral caspase inhibitor
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceZ-Val-Ala-Asp-CH₂F*
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
219007-1MGCN 07790788048648
219007-250UGCN 04055977202021

Documentation

Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Caspase Inhibitor VI - CAS 161401-82-7 - Calbiochem 分析证书

标题批号
219007

参考

参考信息概述
Misaghi, S., et al. 2004. Chem. Biol. 11, 1677.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

引用

标题
  • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
  • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
  • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision17-July-2014 JSW
    SynonymsZ-VAD-FMK
    DescriptionA cell-permeable, irreversible, and general caspase inhibitor. Also reported to inhibit Peptide: N-glycanase (PNGase) in vitro and in vivo. Useful for studies involving recombinant, isolated, and purified caspase enzymes. Unlike Caspase Inhibitor I (Cat. No. 627610), this inhibitor does not require pretreatment with esterase for in vitro studies.
    FormOff-white solid
    CAS number161401-82-7
    Chemical formulaC₂₁H₂₈FN₃O₇
    Peptide SequenceZ-Val-Ala-Asp-CH₂F*
    Structure formulaStructure formula
    Purity≥98% by HPLC
    SolubilityDMSO (9 mg/ml)
    Storage Protect from moisture
    -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesMisaghi, S., et al. 2004. Chem. Biol. 11, 1677.
    Citation
  • Liwei Chen, et al. (2005) Chemical ablation of androgen receptor in prostate cancer cells by the histone deacetylase inhibitor LAQ824. Molecular Cancer Therapeutics 4, 1311-1319.
  • Heui-Young Ryu, et al. (2005) Environmental Chemical-Induced Bone Marrow B Cell Apoptosis: Death Receptor-Independent Activation of a Caspase-3 to Caspase-8 Pathway. Molecular Pharmacology 68, 1087-1096.
  • Yumin Zhang, et al. (2004) Peroxynitrite-Induced Neuronal Apoptosis is Mediated by Intracellular Zinc Release and 12-Lipoxygenase Activation. Journal of Neuroscience 24, 10616-10627.
  • Dong Zhang, et al. (2001) Granzymes A and B Directly Cleave Lamins and Disrupt the Nuclear Lamina During Granule-Mediated Cytolysis. Proceedings of the National Academy of Science USA 98, 5746-5751.
  • Brian L. Webb, Elsa Jimenez and G. Steven Martin. (2000) v-Src Generates a p53-Independent Apoptotic Signal. Molecular and Cellular Biology 20, 9271-9280.
    		•