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400015 Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem

400015
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
154674-81-4C₃₃H₄₂N₄O₁₀

Products

产品目录编号包装 数量 / 包装
400015-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
Catalogue Number400015
Brand Family Calbiochem®
SynonymsICE Inhibitor IV, Ac-YVAD-AOM
References
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
Product Information
CAS number154674-81-4
ATP CompetitiveN
FormWhite solid
Hill FormulaC₃₃H₄₂N₄O₁₀
Chemical formulaC₃₃H₄₂N₄O₁₀
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcaspase-1
Purity≥96% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
400015-1MGCN 07790788049935

Documentation

Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem 分析证书

标题批号
400015

参考

参考信息概述
Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision01-April-2011 RFH
SynonymsICE Inhibitor IV, Ac-YVAD-AOM
DescriptionHighly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
FormWhite solid
CAS number154674-81-4
Chemical formulaC₃₃H₄₂N₄O₁₀
Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
Structure formulaStructure formula
Purity≥96% by HPLC
SolubilityDMSO (5 mg/ml)
Storage Protect from moisture
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.