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390238 Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem

A cell-permeable powerful DNA topoisomerase I inhibitor.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 10-Hydroxycamptothecin, HCPT

Primary Target: DNA topoisomerase I
390238
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
64439-81-2C₂₀H₁₆N₂O₅

Products

产品目录编号包装 数量 / 包装
390238-25MGCN 塑胶安瓿;塑胶针药瓶 25 mg
Description
OverviewA cell-permeable powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Has selective inhibitory effect on the phosphorylation of histone H1 and H3, but less effect on other histones.
Catalogue Number390238
Brand Family Calbiochem®
Synonyms10-Hydroxycamptothecin, HCPT
References
ReferencesZhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.
Product Information
CAS number64439-81-2
ATP CompetitiveN
FormPale yellow powder
Hill FormulaC₂₀H₁₆N₂O₅
Chemical formulaC₂₀H₁₆N₂O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetDNA topoisomerase I
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
390238-25MGCN 04055977189988

Documentation

Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Camptothecin, 10-Hydroxy-, Camptotheca acuminata - CAS 64439-81-2 - Calbiochem 分析证书

标题批号
390238

参考

参考信息概述
Zhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-July-2008 RFH
Synonyms10-Hydroxycamptothecin, HCPT
DescriptionA cell-permeable, powerful DNA topoisomerase I inhibitor. Reduces DNA synthesis in vitro in murine hepatoma cells. Inhibits the proliferation of hepatoma HepG2, Bcl-7402 and Bcl-7404 cells in a dose-dependent manner. Has selective inhibitory effect on the phosphorylation of histones H1 and H3, but is less effective on other histones.
FormPale yellow powder
CAS number64439-81-2
Chemical formulaC₂₀H₁₆N₂O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesZhang, X.W., et al. 1999. Anticancer Drugs. 10, 569.
Ling, Y.H., et al. 1993. Anticancer Res. 13, 1613.
Wani, M.C., and Wall, M.E. 1969. J. Org. Chem. 34, 1364.