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03-34-0051 Calpeptin - CAS 117591-20-5 - Calbiochem

Calpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Benzyloxycarbonylleucyl-norleucinal

Primary Target: Calpain-1
03-34-0051
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
117591-20-5C₂₀H₃₀N₂O₄

Products

产品目录编号包装 数量 / 包装
03-34-0051-100MGCN 塑胶安瓿;塑胶针药瓶 100 mg
03-34-0051-25MGCN 塑胶安瓿;塑胶针药瓶 25 mg
03-34-0051-5MGCN 塑胶安瓿;塑胶针药瓶 5 mg
Description
OverviewA cell-permeable calpain inhibitor (ID50 = 52 nM for calpain-1; ID50 = 34 nM for calpain-2; ID50 = 138 nM for papain). Inhibits the Ca2+-stimulated cleavage of p35 to p25 by calpain. Modulates the processing of β-amyloid precursor protein to β-amyloid (Aβ). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore-induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
Catalogue Number03-34-0051
Brand Family Calbiochem®
SynonymsBenzyloxycarbonylleucyl-norleucinal
References
ReferencesLee, M.S., et al. 2000. Nature 405, 360.
Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Shiba, E., et al. 1996. Anticancer Res. 16, 773.
Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
Product Information
CAS number117591-20-5
ATP CompetitiveN
FormWhite to off-white solid
Hill FormulaC₂₀H₃₀N₂O₄
Chemical formulaC₂₀H₃₀N₂O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationCalpeptin, CAS 117591-20-5, is a cell-permeable inhibitor of calpain 1 and 2 (ID50 = 52 nM for calpain-1; and 34 nM for calpain-2) and papain (ID50 = 138 nM)
Biological Information
Primary TargetCalpain-1
Primary Target IC<sub>50</sub>ID50 = 52 nM for calpain-1; 34 nM for calpain-2; 138 nM for papain
Purity≥94% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Leu-Nle-CHO
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
03-34-0051-100MGCN 04055977206838
03-34-0051-25MGCN 04055977206845
03-34-0051-5MGCN 04055977206852

Documentation

Calpeptin - CAS 117591-20-5 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Calpeptin - CAS 117591-20-5 - Calbiochem 分析证书

标题批号
03-34-0051

参考

参考信息概述
Lee, M.S., et al. 2000. Nature 405, 360.
Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
Shiba, E., et al. 1996. Anticancer Res. 16, 773.
Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.

引用

标题
  • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
    		•
    数据表

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision08-October-2007 JSW
    SynonymsBenzyloxycarbonylleucyl-norleucinal
    DescriptionA cell-permeable calpain inhibitor. Inactivates calpain I (ID50 = 52 nM), calpain II (ID50 = 34 nM), and papain (ID50 = 138 nM). Promotes neurite elongation in differentiating PC12 cells. Prevents Ca2+-ionophore induced degradation of actin binding protein and P235 in platelets. Inhibits myosin light chain phosphorylation in platelets stimulated by collagen, ionomycin, or thrombin. Inhibits the growth of estrogen receptor positive breast cancer cells.
    FormWhite to off-white solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number117591-20-5
    Chemical formulaC₂₀H₃₀N₂O₄
    Peptide SequenceZ-Leu-Nle-CHO
    Structure formulaStructure formula
    Purity≥94% by HPLC
    SolubilityDMF (5 mg/ml) or DMSO (5 mg/ml). Dissolve in a minimal amount of DMF or DMSO then add H₂O, buffer or medium just prior to use.
    Storage -20°C
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
    Toxicity Standard Handling
    ReferencesLee, M.S., et al. 2000. Nature 405, 360.
    Yamazaki, T., et al. 1997. Biochemistry 27, 8377.
    Klafki, H., et al. 1996. J. Biol. Chem. 271, 28655.
    Shiba, E., et al. 1996. Anticancer Res. 16, 773.
    Pinter, M., et al. 1994. Neurosci. Lett. 170, 91.
    Saito, K., and Nixon, R.A. 1993. Neurochem. Res. 18, 231.
    Tsujinaka, T., et al. 1988. Biochem. Biophys. Res. Commun. 153, 1201.
    Citation
  • Rosenberger, G., et al. 2005. Journal of Biological Chemistry 280, 6879.
  • Rios-Doria, J., et al. 2004. Cancer Research 64, 7237.
    		•