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208745 Sigma-AldrichCalpain Inhibitor VI - CAS 190274-53-4 - Calbiochem

The Calpain Inhibitor VI, also referenced under CAS 190274-53-4, controls the biological activity of Calpain. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
Data Sheet

同义词: N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017

Primary Target: µ-calpain

Recommended Products

概述

Replacement Information

重要规格表

CAS #	Empirical Formula
190274-53-4	C₁₇H₂₅FN₂O₄S

Products

产品目录编号	包装	数量 / 包装
208745-1MGCN	塑胶安瓿;塑胶针药瓶	1 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹
208745-5MGCN	塑胶安瓿;塑胶针药瓶	5 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A potent, cell-permeable, reversible inhibitor of calpain (IC₅₀ = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC₅₀ = 15 nM) and L (IC₅₀ = 1.6 nM). Reduces bFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured lenses.
Catalogue Number	208745
Brand Family	Calbiochem®
Synonyms	N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017

References
References	Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

References

Inoue, J., et al. 2003. J. Med. Chem. 46, 868.
Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280.
Mathur, P., et al. 2000. Curr. Eye Res. 21, 926.
Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16.
Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271.
Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623.
Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

Product Information
CAS number	190274-53-4
ATP Competitive	N
Declaration	Sold under license of U.S. Patent 6,551,999
Form	White lyophilized solid
Hill Formula	C₁₇H₂₅FN₂O₄S
Chemical formula	C₁₇H₂₅FN₂O₄S
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Primary Target	µ-calpain
Primary Target IC<sub>50</sub>	7.5 nM for µ-calpain and 78 nM for m-calpain; 15 nM and 1.6 nM against cathepsin B and L, respectively
Purity	≥97% by HPLC

Physicochemical Information
Cell permeable	Y
Peptide Sequence	4-Fluorophenylsulfonyl-Val-Leu-CHO

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Standard Handling
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
208745-1MGCN	04055977202816
208745-5MGCN	04055977202823

Documentation

Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Calpain Inhibitor VI - CAS 190274-53-4 - Calbiochem 分析证书

标题	批号
208745	输入批号

参考

参考信息概述
Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

参考信息概述

小册子

标题
Caspases and other Apoptosis Related Tools Brochure

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	19-February-2014 JSW
Synonyms	N-(4-Fluorophenylsulfonyl)-L-valyl-L-leucinal, SJA6017
Description	A cell-permeable peptide aldehyde that acts as a potent and reversible inhibitor of calpain (IC₅₀ = 7.5 nM for µ-calpain and 78 nM for m-calpain). Also potently inhibits cathepsin B (IC₅₀ = 15 nM) and cathepsin L (IC₅₀ = 1.6 nM). Reduces βFGF-induced angiogenesis in rat cornea and prevents selenite cataract formation in rats. Reduces A23187-induced nuclear opacity and proteolysis of crystallins and α-spectrin in cultured rat lenses.
Form	White lyophilized solid
Intert gas (Yes/No)	Packaged under inert gas
CAS number	190274-53-4
Chemical formula	C₁₇H₂₅FN₂O₄S
Peptide Sequence	4-Fluorophenylsulfonyl-Val-Leu-CHO
Structure formula
Purity	≥97% by HPLC
Solubility	DMSO (5 mg/ml)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 3 months at -20°C.
Toxicity	Standard Handling
References	Inoue, J., et al. 2003. J. Med. Chem. 46, 868. Tamada, Y., et al. 2001. Curr. Eye Res. 22, 280. Mathur, P., et al. 2000. Curr. Eye Res. 21, 926. Nath, R., et al. 2000. Biochem. Biophys. Res. Commun. 274, 16. Tamada, Y., et al. 2000. J. Ocul. Pharmacol. Ther. 16, 271. Fukiage, C., et al. 1998. Curr. Eye Res. 17, 623. Fukiage, C., et al. 1997. Biochim. Biophys. Acta 1361, 304.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Proteases Inhibitors > Calpain Inhibitors

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