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14-547 CaM Kinase IV Protein, active, 10 µg

Active, C-terminal His6-tagged, recombinant, full-length, human CaM Kinase IV, for use in Kinase Assays.

CaM Kinase IV Protein, active, 10 µg MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
14-547
10 µg  Also available in 250 µg size --call for pricing and availability and reference catalog number 14-547M when ordering the 250 µg size.
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue Number14-547
Brand Family Upstate
Trade Name
  • Upstate
DescriptionCaM Kinase IV Protein, active, 10 µg
OverviewC-terminal His6-tagged, recombinant, full-length, human CaM Kinase IV
References
Product Information
Quality LevelMQ100
Applications
ApplicationActive, C-terminal His6-tagged, recombinant, full-length, human CaM Kinase IV, for use in Kinase Assays.
Key Applications
  • Kinase Assay
Biological Information
Sourceexpressed by baculovirus in Sf21 insect cells
Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
Entrez Gene Number
Entrez Gene SummaryThe product of this gene belongs to the serine/threonine protein kinase family, and to the Ca(2+)/calmodulin-dependent protein kinase subfamily. This enzyme is a multifunctional serine/threonine protein kinase with limited tissue distribution, that has been implicated in transcriptional regulation in lymphocytes, neurons and male germ cells.
Gene Symbol
  • CAMK4
  • MGC36771
  • CaMK-GR
Protein TargetCaMKIV
Purification MethodNi2+/NTA-agarose
Target Sub-FamilyCAMK
UniProt Number
UniProt SummaryFUNCTION: SwissProt: Q16566 # Calcium/calmodulin-dependent protein kinase belonging to a proposed calcium-triggered signaling cascade. May be involved in transcriptional regulation. May be involved in regulation of microtubule dynamics. In vitro, phosphorylates CREB1, CREBBP, PRM2, MEF2A, MEF2D and STMN1/OP18. May be involved in spermatogenesis. May play a role in the consolidation/retention of hippocampus-dependent long-term memory (By similarity).
SIZE: 473 amino acids; 51926 Da
SUBUNIT: Monomer (By similarity). Interacts with serine/threonine protein phosphatase 2A catalytic subunit, PPP2CA or PPP2CB. The interaction with PP2CA or PP2CB is mutually exclusive with binding to Ca(2+)/calmodulin.
SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=Substantial localization in certain neuronal nuclei. In spermatids associated with chromatin and nuclear matrix (By similarity).
TISSUE SPECIFICITY: Expressed in epithelial ovarian cancer tissue.
PTM: Autophosphorylated and phosphorylated by CAMKK1 and CAMKK2 (By similarity). Dephosphorylated by serine/threonine protein phosphatase 2A, probably on Thr-200.
SIMILARITY: SwissProt: Q16566 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. & Contains 1 protein kinase domain.
Molecular Weight52.9kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by phosphorylation of MAPKAP Kinase 2 Substrate Peptide
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions6 months at -70°C
Packaging Information
Material Size10 µg
Material PackageAlso available in 250 µg size --call for pricing and availability and reference catalog number 14-547M when ordering the 250 µg size.
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
14-547 04053252470288

相关产品和应用

Alternative Packsize

产品目录编号 描述
14-547M CaM Kinase IV Protein, active, 250 µg

产品族

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种类

Life Science Research > Proteins and Enzymes > Purified Kinases
Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases