203890 Sigma-AldrichCRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem
CRAC Channel Inhibitor, BTP2, CAS 223499-30-7, is a cell-permeable, potent blocker of Stim1 and Orai1-coupled Ca2+ release-activated Ca2+ channel-mediated SOCE in RBL-2H3 cells (IC50 = 590 nM).
More>> CRAC Channel Inhibitor, BTP2, CAS 223499-30-7, is a cell-permeable, potent blocker of Stim1 and Orai1-coupled Ca2+ release-activated Ca2+ channel-mediated SOCE in RBL-2H3 cells (IC50 = 590 nM). Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: [N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], Pyr2, TPRC3 Channel Inhibitor II
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 223499-30-7 | C₁₅H₉F₆N₅OS |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
|---|---|---|---|
| 203890-5MGCN | 塑胶安瓿;塑胶针药瓶 | 5 mg |
| Description | |
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| Overview | A cell-permeable pyrazole that acts as a more potent blocker of Stim1 and Orai1-coupled CRAC (Ca2+ release-activated Ca2+) channel-mediated SOCE (store-operated Ca2+ entry) in RBL-2H3 cells (IC50 = 590 nM by Fura-2; peak current density pA/pF = -1.13 and -7.50, respectively, with or without 3 µM BTP2/Pyr2 by whole cell clamp) than the transient receptor potential cation channel TRPC3-mediated ROCE (receptor-operated Ca2+ entry) inTRPC3-expressing HEK293 cells (IC50 = 4.21 µM by Fura-2; pA/pF = -1.54 and -18.50, respectively, with or without 3 µM BTP2/Pyr2). A great complement to Pyr 3 (Cat. No. 648490), Pyr6, and Pyr10 in Ca2+ signaling studies. |
| Catalogue Number | 203890 |
| Brand Family | Calbiochem® |
| Synonyms | [N-{4-[3,5-bis(Trifluoromethyl)-1H-pyrazol-1-yl]phenyl}-4-methyl-1,2,3-thiadiazole-5-carboxamide], Pyr2, TPRC3 Channel Inhibitor II |
| Product Information | |
|---|---|
| CAS number | 223499-30-7 |
| ATP Competitive | N |
| Form | Solid |
| Hill Formula | C₁₅H₉F₆N₅OS |
| Chemical formula | C₁₅H₉F₆N₅OS |
| Reversible | N |
| Structure formula Image | |
| Quality Level | MQ100 |
| Biological Information | |
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| Primary Target | CRAC Channel |
| Primary Target IC<sub>50</sub> | 590 nM by Fura-2 |
| Purity | ≥95% by HPLC |
| Physicochemical Information | |
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| Cell permeable | Y |
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| Packaging Information | |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 203890-5MGCN | 04055977204070 |
Documentation
CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem MSDS
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CRAC Channel Inhibitor, BTP2 - CAS 223499-30-7 - Calbiochem 分析证书
| 标题 | 批号 |
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| 203890 |
参考
| 参考信息概述 |
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| Schleifier, H., et al. 2012. Br J Pharmacol In Press Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 5370. Yonetoku, Y., et al. 2006. Bioorg. Med. Chem. 14, 4750. Zitt, C., et al. 2004. J. Biol. Chem. 279, 12927. Trevillyan, J.M., et al. 2001. J. Biol. Chem. 276, 48118. Djuric, S.W., et al. 2000. J. Med. Chem. 43, 2975. |
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Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.
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