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205531 CA-074 Me - Calbiochem

CA-074 Me, CAS 147859-80-1, is a cell-permeable analog of CA-074 that acts as an irreversible inhibitor of intracellular cathepsin B.

CA-074 Me - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: Cathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester

Primary Target: cathepsin B
205531
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概述

Replacement Information

重要规格表

Empirical Formula
C₁₉H₃₁N₃O₆

Products

产品目录编号包装 数量 / 包装
205531-1MGCN 塑胶安瓿;塑胶针药瓶 1 mg
Description
OverviewA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B. Reported to inhibit bone resorption in rodent models and shown to inhibit B16 melanoma cell invasion in vitro.
Catalogue Number205531
Brand Family Calbiochem®
SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
References
ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₉H₃₁N₃O₆
Chemical formulaC₁₉H₃₁N₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target IC<sub>50</sub>2.24 nM against cathepsin B
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
205531-1MGCN 07790788048433

Documentation

CA-074 Me - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

CA-074 Me - Calbiochem 分析证书

标题批号
205531

参考

参考信息概述
Sever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.

引用

标题
IM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-May-2008 RFH
SynonymsCathepsin B Inhibitor IV, [L-3-trans-(Propylcarbamoyl)oxirane-2-carbonyl]-L-isoleucyl-L-proline Methyl Ester
DescriptionA cell-permeable analog of CA-074 (Cat. No. 205530) that acts as an irreversible inhibitor of intracellular cathepsin B.
FormWhite solid
Chemical formulaC₁₉H₃₁N₃O₆
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesSever, N., et al. 2002. Biol. Chem. 383, 839.
Authier, F., et al. 1999. J. Biol. Chem. 274, 33723.
Hill, P.A., et al. 1994. J. Cell Biochem. 56, 118.
Buttle, D.J., et al. 1992. Arch. Biochem. Biophys. 299, 377.
CitationIM, E., et al. 2005. Molecular Biology of the Cell 16, 3488.