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200499 Sigma-AldrichBexarotene - CAS 153559-49-0 - Calbiochem

A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner.

Bexarotene - CAS 153559-49-0 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
Data Sheet

同义词: 4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

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概述

Replacement Information

重要规格表

CAS #	Empirical Formula
153559-49-0	C₂₄H₂₈O₂

Products

产品目录编号	包装	数量 / 包装
200499-50MGCN	玻璃瓶	50 mg	添加到收藏夹添加到收藏夹添加到我的收藏夹

Description
Overview	A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.
Catalogue Number	200499
Brand Family	Calbiochem®
Synonyms	4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid

References
References	Cramer, P.E., et al. 2012. Science Exp. 335, 1503.

Product Information
CAS number	153559-49-0
Form	White powder
Hill Formula	C₂₄H₂₈O₂
Chemical formula	C₂₄H₂₈O₂
Reversible	Y
Structure formula Image
Quality Level	MQ100

Applications

Biological Information
Purity	≥99% by HPLC

Physicochemical Information
Cell permeable	Y

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements

Storage and Shipping Information
Ship Code	Ambient Temperature Only
Toxicity	Regulatory Review
Storage	-20°C
Protect from Light	Protect from light
Do not freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

Packaging Information
Packaged under inert gas	Packaged under inert gas

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
200499-50MGCN	04055977221558

Documentation

Bexarotene - CAS 153559-49-0 - Calbiochem MSDS

职位
物料安全数据表 (MSDS)

Bexarotene - CAS 153559-49-0 - Calbiochem 分析证书

标题	批号
200499	输入批号

参考

参考信息概述
Cramer, P.E., et al. 2012. Science Exp. 335, 1503.

数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision	27-June-2012 JSW
Synonyms	4-(1-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)vinyl)benzoic acid
Description	A retinoid X receptor (RXR) agonist that can permeate the blood-brain barrier and rapidly reduce Aβ40 and Aβ42 levels in APP/PS1 mice in an ApoE-dependent manner (25% reduction in 6 h and 50% reduction in 72 h). Causes a rapid reversal of cognitive, social, and olfactory deficts. Shown to progressively enhance the expression of ApoE and ATP-binding cassette transporters ABCA1 and ABCG1. Also stimulates the secretion of highly lapidated HDL particles in primary microglia and astrocytes. Does not affect the levels of Aβ proteases, insulin degrading enzyme, and neprilysin.
Form	White powder
Intert gas (Yes/No)	Packaged under inert gas
CAS number	153559-49-0
Chemical formula	C₂₄H₂₈O₂
Structure formula
Purity	≥99% by HPLC
Solubility	DMSO (50 mg/ml; clear, colorless solution)
Storage	Protect from light -20°C
Do Not Freeze	Ok to freeze
Special Instructions	Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity	Regulatory Review
References	Cramer, P.E., et al. 2012. Science Exp. 335, 1503.

种类

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Activators > Other Activators/Agonists

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