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196440 Batimastat - CAS 130370-60-4 - Calbiochem

Batimastat, CAS 130370-60-4, is a potent inhibitor of a several metalloproteinases, including MMP-1, 2, 3, 7, 9, ΔMT1, ADAM8 & ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3 & 19 nM, respectively).

Batimastat - CAS 130370-60-4 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: (4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94

196440
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
130370-60-4C₂₃H₃₁N₃O₄S₂

Products

产品目录编号包装 数量 / 包装
196440-5MGCN 玻璃瓶 5 mg
Description
OverviewA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo. Also available as a 25 mM solution in DMSO (Cat. No. 508408).
Catalogue Number196440
Brand Family Calbiochem®
Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
References
ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.
Product Information
CAS number130370-60-4
FormOff-white solid
Hill FormulaC₂₃H₃₁N₃O₄S₂
Chemical formulaC₂₃H₃₁N₃O₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationBatimastat, CAS 130370-60-4, is a potent inhibitor of a several metalloproteinases, including MMP-1, 2, 3, 7, 9, ΔMT1, ADAM8 & ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3 & 19 nM, respectively).
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
196440-5MGCN 04055977206500

Documentation

Batimastat - CAS 130370-60-4 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Batimastat - CAS 130370-60-4 - Calbiochem 分析证书

标题批号
196440

参考

参考信息概述
Schlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-August-2010 RFH
Synonyms(4-N-Hydroxyamino)-2R-isobutyl-3S-(thienylthiomethyl)succinyl)-L-phenylalanine-N-methylamide, BB-94
DescriptionA Marimastat (Cat. No. 444289) type of peptidyl hydroxamate-based inhibitor that potently inhibits a broad-spectrum of metalloproteinases, including MMP-1, MMP-2, MMP-3/stromelysin, MMP-7/matrilysin, MMP-9, ΔMT1 (MMP-14 without TM domain), ADAM8, and ADAM17/TACE (IC50 = 3, 4, 20, 6, 4, 2.08, 51.3, and 19 nM, respectively), by targeting both the substrate binding site and the active-site Zn2+, while being much less potent toward ACE (Angiotensin Converting Enzyme) or α-secretase (IC50 = 1.6 and 3.3 µM, respectively). Batimastat is widely used in studying the involvement of MMPs in cancinogenesis and non-cancer pathological processes both in cultures in vitro and in animals in vivo.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number130370-60-4
Chemical formulaC₂₃H₃₁N₃O₄S₂
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (50 mg/ml)
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesSchlomann, U., et al. 2002. J. Biol. Chem. 277, 48210.
Whittaker, M., et al. 1999. Chem. Rev. 99, 2735.
Parvathy, S., et al. 1998. Biochemistry 37, 1680.
Parvathy, S., et al. 1998. FEBS Lett. 431, 63.
Yamamoto, M., et al. 1998. J. Med. Chem. 41, 1209.
Moss, M.L., et al. 1997. Nature 385, 733.
Eccles, S.A., et al. 1996. Cancer Res. 56, 2815.
Brown, P.D. 1995. Advan. Enzyme Regul. 35, 293.
Wang, X., et al. 1994. Cancer Res. 54, 4726.
Davies, B., et al. 1993. Cancer Res. 53, 2087.