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196322 Baicalein - CAS 491-67-8 - Calbiochem

A cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC₅₀= 120 nM) and reverse transcriptase.

Baicalein - CAS 491-67-8 - Calbiochem MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

同义词: 5,6,7-Trihydroxyflavone

196322
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概述

Replacement Information

Products

产品目录编号包装 数量 / 包装
196322-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Protects cortical neurons from β-amyloid induced toxicity. Reduces leukotriene biosynthesis and inhibits the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induced arthritis. Reported to inhibit microsomal lipid peroxidation by forming an iron-baicalein complex. Inhibits topoisomerase II and induces cell death in hepatocellular carcinoma cell lines. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated protein kinase C.
Catalogue Number196322
Brand Family Calbiochem®
Synonyms5,6,7-Trihydroxyflavone
References
ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
Product Information
CAS number491-67-8
ATP CompetitiveN
FormYellow solid
Hill FormulaC₁₅H₁₀O₅
Chemical formulaC₁₅H₁₀O₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Target12-lipoxygenase
Primary Target IC<sub>50</sub>120 nM against 12-lipoxygenase
Purity≥98% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
196322-10MGCN 04055977206463

Documentation

Baicalein - CAS 491-67-8 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Baicalein - CAS 491-67-8 - Calbiochem 分析证书

标题批号
196322

参考

参考信息概述
Leabeau, A., et al. 2001. Neuroreport 12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-August-2018 JSW
Synonyms5,6,7-Trihydroxyflavone
DescriptionA cell-permeable flavone that inhibits the activity of 12-lipoxygenase (IC50 = 120 nM) and reverse transcriptase. Reduces leukotriene biosynthesis and the release of lysosomal enzymes. Also inhibits cellular Ca2+ uptake and mobilization, and adjuvant-induces arthritis. Potentiates contractile responses to nerve stimulation. Inhibits protein tyrosine kinase and PMA-stimulated PKC.
FormYellow solid
CAS number491-67-8
Chemical formulaC₁₅H₁₀O₅
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (20 mg/ml) or Acetone
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Irritant
Merck USA index14, 942
ReferencesLeabeau, A., et al. 2001. Neuroreport 12, 2199.
Gao, D., et al. 1996. Biochem. Mol. Biol. Int. 39, 215.
Matsuzaki, Y., et al. 1996. Jpn. J. Cancer Res. 87, 170.
Huang, H.C., et al. 1994. Eur. J. Pharmacol. 268, 73.
Butenko, I.G., et al. 1993. Agents Actions 39, C49.
Abe, K., et al. 1990. Chem. Pharm. Bull. 38, 209.
Kimura, Y., et al. 1987. Biochim. Biophys. Acta 922, 278.
Sekiya, K., and Okuda, H. 1982. Biochem. Biophys. Res. Commun. 105, 1090.