Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

196000 Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem

This product can no longer be ordered through emdmillipore.com. Please refer to (Cat. No. 196000) on sigmaaldrich.com.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Primary Target: vacuolar type H+ ATPase
196000
Purchase on Sigma-Aldrich

概述

Replacement Information

重要规格表

CAS #Empirical Formula
88899-55-2C₃₅H₅₈O₉

Products

产品目录编号包装 数量 / 包装
196000-10UGCN 塑胶安瓿;塑胶针药瓶 10 μg
196000-1SETCN 玻璃瓶 1 set
Description
OverviewA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 500 pM). A valuable tool for distinguishing among different types of ATPases. Blocks lysosomal cholesterol trafficking in macrophages and is known to interfere with pH regulation in brain cells. Exhibits cytotoxic effects on a number of cell lines in a cell viability assay. Reported to selectively inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). The InSolution™ format with a purity of ≥97% by HPLC in 90% DMSO is also available (Cat. No. 508409).
Note: 1 set = 3 x 10 µg
Catalogue Number196000
Brand Family Calbiochem®
References
ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.
Product Information
CAS number88899-55-2
FormWhite solid
Hill FormulaC₃₅H₅₈O₉
Chemical formulaC₃₅H₅₈O₉
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetvacuolar type H+ ATPase
Primary Target IC<sub>50</sub>500 pM
Purity≥90% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 22-26-36

Do not breathe dust.
In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
196000-10UGCN 04055977206456
196000-1SETCN 04055977206449

Documentation

Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Bafilomycin A1, Streptomyces griseus - CAS 88899-55-2 - Calbiochem 分析证书

标题批号
196000

参考

参考信息概述
Sinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2010 JSW
DescriptionA macrolide antibiotic that acts as a specific inhibitor of vacuolar-type H+-ATPase (V-type; Ki = 0.5 nM) and is a valuable tool for distinguishing among different types of ATPases. Reported to selectivity inhibit β-secretase, an enzyme involved in the processing of amyloid precursor protein (APP). Blocks lysosomal cholesterol trafficking in macrophages. Known to interfere with pH regulation in brain cells. Inhibits bone resorption both in vivo and in vitro. Has been shown to exhibit cytotoxic effects on a number of cell lines in a cell viability assay.
FormWhite solid
CAS number88899-55-2
Chemical formulaC₃₅H₅₈O₉
Structure formulaStructure formula
Purity≥90% by HPLC
SolubilityDMSO (100 µM) or Ethanol
Storage Protect from light
-20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). DMSO stock solutions are stable for up to 1 year at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesSinha, S., and Lieberburg, I. 1999. Proc. Natl. Acad. Sci. USA 96, 11049.
Calvert, C.M., and Sanders, D. 1995. J. Biol. Chem. 270, 7272.
Nishihara, T., et al. 1995. Biochem. Biophys. Res. Commun. 269, 255.
Crider, B.P., et al. 1994. J. Biol. Chem. 269, 17379.
Palokangas, H., et al. 1994. J. Biol. Chem. 269, 17577.
Sundquist, K.T., and Marks, S.C., Jr. 1994. J. Bone Miner. Res. 9, 1575.
Drose, S., et al. 1993. Biochemistry 32, 3902.
Furuchi, T., et al. 1993. J. Biol. Chem. 268, 27345.
Bowman, E.J., et al. 1988. Proc. Natl. Acad. Sci. USA 85, 7972.