182516 Sigma-AldrichArp2/3 Complex Inhibitor II, CK-869 - CAS 388592-44-7 - Calbiochem
The Arp2/3 Complex Inhibitor II, CK-869 controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications.
More>> The Arp2/3 Complex Inhibitor II, CK-869 controls the biological activity of Arp2/3. This small molecule/inhibitor is primarily used for Cell Structure applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: Actin Assembly Inhibitor XIV, 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869
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概述
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重要规格表
| CAS # | Empirical Formula |
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| 388592-44-7 | C₁₇H₁₆BrNO₃S |
Products
| 产品目录编号 | 包装 | 数量 / 包装 | |
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| 182516-25MGCN | 玻璃瓶 | 25 mg |
| Description | |
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| Overview | A cell-permeable thiazolidinone compound that inhibits actin assembly mediated by actin-related protein Arp2/3 complex of human and bovine, but not yeast, species (IC50 = 11 µM against bovine Arp2/3). Shown to inhibit the actin filament "comet tails" formation around intracellular Listeria in infected SKOV3 cells (IC50 = 7 µM). Structrual studies indicate that CK-869 targets the hydrophobic core in subdomain 1 of Arp3. CK-666 (Cat. No. 182515) and CK-869 exhibit different modes of binding, resulting in their different yeast cross-reactivities. Supplied as a racemic mixture of the active 2S and the inactive 2R enantiomers. CK-312 (Cat. No. 182518) can serve as a negative control. |
| Catalogue Number | 182516 |
| Brand Family | Calbiochem® |
| Synonyms | Actin Assembly Inhibitor XIV, 2-(3-Bromophenyl)-3-(2,4-dimethoxyphenyl)-1,3-thiazolidin-4-one, racemic, CK-0157869 |
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| References | Nolen, B.J., et al. 2009. Nature 460, 1031. |
| Product Information | |
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| CAS number | 388592-44-7 |
| Form | Off-white solid |
| Hill Formula | C₁₇H₁₆BrNO₃S |
| Chemical formula | C₁₇H₁₆BrNO₃S |
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| Quality Level | MQ100 |
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| Purity | ≥95% by HPLC |
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| Packaged under inert gas | Packaged under inert gas |
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| Specifications |
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| Global Trade Item Number | |
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| 产品目录编号 | GTIN |
| 182516-25MGCN | 04055977205060 |
Documentation
Arp2/3 Complex Inhibitor II, CK-869 - CAS 388592-44-7 - Calbiochem MSDS
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Arp2/3 Complex Inhibitor II, CK-869 - CAS 388592-44-7 - Calbiochem 分析证书
| 标题 | 批号 |
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| 182516 |
参考
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| Nolen, B.J., et al. 2009. Nature 460, 1031. |