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178494 Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem

178494
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
426834-38-0C₁₅H₁₀ClF₃N₂O₃

Products

产品目录编号包装 数量 / 包装
178494-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewA cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases.
Catalogue Number178494
Brand Family Calbiochem®
SynonymsNS3694
References
ReferencesLademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
Product Information
CAS number426834-38-0
ATP CompetitiveN
FormWhite solid
Hill FormulaC₁₅H₁₀ClF₃N₂O₃
Chemical formulaC₁₅H₁₀ClF₃N₂O₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetApoptosome complex formation
Primary Target IC<sub>50</sub>50 µM completely blocks TNF-α-induced death in MCF-casp3 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
178494-10MGCN 04055977204803

Documentation

Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem 分析证书

标题批号
178494

参考

参考信息概述
Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2009 JSW
SynonymsNS3694
DescriptionA cell-permeable diarylurea compound that specifically prevents the formation of the active ~700 kDa apoptosome complex induced by cytochrome c release. Alters cytochrome c and ATP-triggered association between Apaf-1 and caspase-9. Protects against apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by Fas ligand (FasL). Does not inhibit cytochrome c release or the activity of caspase-3 and -9.
FormWhite solid
CAS number426834-38-0
Chemical formulaC₁₅H₁₀ClF₃N₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml). Slightly soluble in ethanol.
Storage Protect from light
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesLademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829.