178494 Sigma-AldrichApoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem
The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications.
More>> The Apoptosis Inhibitor II, NS3694, also referenced under CAS 426834-38-0, controls the biological activity of Apoptosis. This small molecule/inhibitor is primarily used for Cancer applications. Less<<MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
同义词: NS3694
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概述
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重要规格表
CAS # | Empirical Formula |
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426834-38-0 | C₁₅H₁₀ClF₃N₂O₃ |
Products
产品目录编号 | 包装 | 数量 / 包装 | |
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178494-10MGCN | 塑胶安瓿;塑胶针药瓶 | 10 mg |
Description | |
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Overview | A cell-permeable diarylurea compound that specifically prevents the active ~700-kDa apoptosome complex formation triggered by cytochrome c release, thus blocking apoptosome-mediated caspase activation and cell death (50 µM completely blocks TNF-α-induced death in MCF-casp3 cells). Unlike M50054 (Cat. No. 178488), NS3694 exhibits no effect on apoptosome-independent caspase activation and cell death induced by FasL. Inhibits neither cytochrome c release nor the enzymatic activity of caspases. |
Catalogue Number | 178494 |
Brand Family | Calbiochem® |
Synonyms | NS3694 |
References | |
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References | Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829. |
Product Information | |
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CAS number | 426834-38-0 |
ATP Competitive | N |
Form | White solid |
Hill Formula | C₁₅H₁₀ClF₃N₂O₃ |
Chemical formula | C₁₅H₁₀ClF₃N₂O₃ |
Reversible | N |
Structure formula Image | |
Quality Level | MQ100 |
Applications |
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Biological Information | |
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Primary Target | Apoptosome complex formation |
Primary Target IC<sub>50</sub> | 50 µM completely blocks TNF-α-induced death in MCF-casp3 cells |
Purity | ≥95% by HPLC |
Physicochemical Information | |
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Cell permeable | Y |
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Safety Information according to GHS |
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Specifications |
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Global Trade Item Number | |
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产品目录编号 | GTIN |
178494-10MGCN | 04055977204803 |
Documentation
Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem MSDS
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Apoptosis Inhibitor II, NS3694 - CAS 426834-38-0 - Calbiochem 分析证书
标题 | 批号 |
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178494 |
参考
参考信息概述 |
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Lademann, U., et al. 2003. Mol. Cell. Biol. 23, 7829. |