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178488 Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem

178488
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概述

Replacement Information

重要规格表

CAS #Empirical Formula
54135-60-3C₁₃H₁₆O₄

Products

产品目录编号包装 数量 / 包装
178488-10MGCN 塑胶安瓿;塑胶针药瓶 10 mg
Description
OverviewA cell-permeable inhibitor of apoptosis induction (IC50 = 67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells). Effects attributable to the inhibition of caspase-3 activation but does not directly inhibit caspase-3 even at 1 mg/ml.
Catalogue Number178488
Brand Family Calbiochem®
SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
References
ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.
Product Information
CAS number54135-60-3
ATP CompetitiveN
FormOff-white solid
Hill FormulaC₁₃H₁₆O₄
Chemical formulaC₁₃H₁₆O₄
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetapoptosis induction
Primary Target IC<sub>50</sub>67 µg/ml in FasL-stimulated WC8 cells, 130 µg/ml in etoposide-stimulated U937 cells
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
178488-10MGCN 04055977204780

Documentation

Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem MSDS

职位

物料安全数据表 (MSDS) 

Apoptosis Inhibitor - CAS 54135-60-3 - Calbiochem 分析证书

标题批号
178488

参考

参考信息概述
Tsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.

小册子

标题
Caspases and other Apoptosis Related Tools Brochure
数据表

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-July-2009 RFH
SynonymsM50054, 2,2ʹ-Methylenebis(1,3-cyclohexanedione)
DescriptionA cell-permeable, bis(cyclohexane-1,3-diketone) that is shown to inhibit apoptosis induction in FasL-stimulated WC8 cells (IC50 = 67 µg/ml) and etoposide-stimulated U937 cells (IC50 = 130 µg/ml). The anti-apoptotic effects have been shown to be attributable to inhibition of caspase-3 activation (IC50 = 334 nM), however it does not exhibit any direct inhibition of caspase-3 enzymatic activity. Shown to inhibit the elevation of the liver enzymes, alanine aminotransferase and aspartate aminotransferase, in a murine model of anti-Fas-induced hepatitis. Topical application has been shown to reduce chemotherapy-induced alopecia (hair loss) in newborn rats.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number54135-60-3
Chemical formulaC₁₃H₁₆O₄
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (20 mg/ml)
Storage Protect from moisture
+2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTsuda, T., et al. 2001. Eur. J. Pharmacol. 433, 37.