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05-590 Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12

Detect phospho-STAT6 (Tyr641) also known as signal transducer & activator of transcription 6 with Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 (mouse monoclonal antibody), that has been demonstrated to work in WB.

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Epigenetics & Nuclear Function Research Sub-Category: Transcription Factors Gene Symbol: STAT6, STAT6C, D12S1644, STAT6B, IL-4-STAT UniProt Number: P42226
05-590
100 µg  
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概述

Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWBMPurifiedMonoclonal Antibody
Description
Catalogue Number05-590
ReplacesMAB3702
Brand Family Upstate
Trade Name
  • Upstate
DescriptionAnti-phospho-STAT6 (Tyr641) Antibody, clone 16E12
References
Product Information
FormatPurified
Presentation100µg of lyophilized thiophilic and size exclusion chromatography purified mouse IgG1 from 1mL 2x PBS / 0.09 % Na-azide / PEG and Sucrose. Reconstitute with 100 µL H2O (15 min, RT) for a final concentration of 1 mg/mL. Store at -20°C.
Quality LevelMQ100
Applications
ApplicationDetect phospho-STAT6 (Tyr641) also known as signal transducer & activator of transcription 6 with Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 (mouse monoclonal antibody), that has been demonstrated to work in WB.
Key Applications
  • Western Blotting
Biological Information
ImmunogenPeptide corresponding to residues of human STAT6 (Tyr641); recognizes STAT6 phosphorylated on Tyrosine 641.
Cloneclone 16E12
HostMouse
Specificityphosphorylated STAT6
IsotypeIgG1
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein plays a central role in exerting IL4 mediated biological responses. It is found to induce the expression of BCL2L1/BCL-X(L), which is responsible for the anti-apoptotic activity of IL4. Knockout studies in mice suggested the roles of this gene in differentiation of T helper 2 (Th2) cells, expression of cell surface markers, and class switch of immunoglobulins.
Gene Symbol
  • STAT6
  • STAT6C
  • D12S1644
  • STAT6B
  • IL-4-STAT
Modifications
  • Phosphorylation
Purification MethodThiophilic adsoption and size exclusion chromatography
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P42226 # Carries out a dual function: signal transduction and activation of transcription. Involved in interleukin-4 signalling.
SIZE: 847 amino acids; 94135 Da
SUBUNIT: Forms a homodimer or a heterodimer with a related family member (By similarity). Interacts with NCOA1 via its C-terminal LXXLL motif.
SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.
PTM: Tyrosine phosphorylated following stimulation by IL-4 and IL- 3 (By similarity).
SIMILARITY: SwissProt: P42226 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain.
Molecular Weight100kDa
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality Assuranceroutinely evaluated by immunoblot on RIPA lysates from IL4-stimulated HepG2 cells
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage Conditions2 years at -20°C
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
05-590 04053252336836

Documentation

Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 MSDS

职位

物料安全数据表 (MSDS) 

Anti-phospho-STAT6 (Tyr641) Antibody, clone 16E12 分析证书

标题批号
Anti-phospho-STAT6 (Tyr641) - 20253 20253
Anti-phospho-STAT6 (Tyr641) - 25346 25346
Anti-phospho-STAT6 (Y641), clone 16E12 3067257
Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2433264 2433264
Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) 3109223
Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 1951497 1951497
Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2110471 2110471
Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2210329 2210329
Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2274021 2274021
Anti-phospho-STAT6 (Y641), clone 16E12 (mouse monoclonal IgG1) - 2326975 2326975
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小册子

标题
Pathways and Biomarkers of JAK/STAT Signaling

技术信息

标题
JAK/STAT Signaling Research Focus