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ABS1004 Sigma-AldrichAnti-phospho-NKCC1 Antibody (Thr212/Thr217)

Anti-phospho-NKCC1 Thr212/Thr217 is an antibody against phospho-NKCC1 for use in Western Blotting, Immunofluorescence.

Anti-phospho-NKCC1 Antibody (Thr212/Thr217) MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书
参考
小册子
技术信息

Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: SLC12A2, NKCC1 UniProt Number: P55011

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	WB, IF	Rb	Serum	Polyclonal Antibody

Description
Catalogue Number	ABS1004
Description	Anti-phospho-NKCC1 Antibody (Thr212/Thr217)
Alternate Names	phospho-NKCC1 Thr212/Thr217 Solute carrier family 12 member 2 Basolateral Na-K-Cl symporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1
Background Information	The Na-K-Cl cotransporter 1 (NKCC1) is a membrane protein coded by the SLC12A2 gene and functions in cellular sodium/potassium/chloride transport and homeostasis. It is widely distributed throughout the body and serves important functions, especially in liquid-secreting glands. Phosphorylation of Thr212/Thr217 in the intracellular N-terminal domain of NKCC1 is correlated with NKCC1 activation.

References

Product Information
Format	Serum
HS Code	3002 15 90
Presentation	Rabbit polyclonal serum with 0.05% sodium azide.
Quality Level	MQ100

Applications
Application	Anti-phospho-NKCC1 Thr212/Thr217 is an antibody against phospho-NKCC1 for use in Western Blotting, Immunofluorescence.
Key Applications	Western Blotting Immunofluorescence
Application Notes	Western Blotting Analysis: A representative lot detected phospho-NKCC1 Thr212/Thr217 in GMB43 and GBM5 cell lysate (Dr. Anders Persson, UCSF) (Grim, R.P., et al. (2012). JBC. 1-31). Immunofluorescence Analysis: A representative lot detected phospho-NKCC1 Thr212/Thr217 in GBM43 human tissiue (Dr. Anders Persson, UCSF) (Grim, R.P., et al. (2012). JBC. 1-31).

Biological Information
Immunogen	Linear peptide corresponding to human phospho-NKCC1 Thr212/Thr217.
Concentration	Please refer to lot specific datasheet.
Host	Rabbit
Specificity	Specific for mature form of phosphorylated NKCC1.
Species Reactivity	Human
Antibody Type	Polyclonal Antibody
Entrez Gene Number	NP_001037
Gene Symbol	SLC12A2 NKCC1
Purification Method	Unpurified
UniProt Number	P55011
Molecular Weight	~250 kDa observed. Likely a dimer of mature form of NKCC1, NKCC1 is glycosylated differently in different cells, leading to uncharacterized band(s) in some lysates.

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Western Blotting in GMB43 cell lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected phospho-NKCC1 Thr212/Thr217 in 10 µg of GMB43 cell lysate.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µL

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
ABS1004	04055977133332

Documentation

Anti-phospho-NKCC1 Antibody (Thr212/Thr217) MSDS

职位
物料安全数据表 (MSDS)

Anti-phospho-NKCC1 Antibody (Thr212/Thr217) 分析证书

标题	批号
Anti-phospho-NKCC1 Thr212/Thr217 - 3224588	3224588
Anti-phospho-NKCC1 Thr212/Thr217 - 3474199	3474199
Anti-phospho-NKCC1 Thr212/Thr217 - 3726147	3726147
Anti-phospho-NKCC1 Thr212/Thr217 - 3909656	3909656
Anti-phospho-NKCC1 Thr212/Thr217 - 4045821	4045821
Anti-phospho-NKCC1 Thr212/Thr217 - 4123894	4123894
Anti-phospho-NKCC1 Thr212/Thr217 - 4149291	4149291
Anti-phospho-NKCC1 Thr212/Thr217 - 4216369	4216369
Anti-phospho-NKCC1 Thr212/Thr217 -2634209	2634209
Anti-phospho-NKCC1 Thr212/Thr217 -2645985	2645985

参考

参考概述	公共医疗ID
The Journal of endocrinology Tiptaft, EM; Jones, MT The Journal of endocrinology 64 9P-10P 1975	163881

小册子

标题
NPI Flyer- Epigenetics and Nuclear Function Feature
New Products - Antibodies, Small Molecule, Inhibitors

技术信息

标题
White Paper: Further considerations of antibody validation and usage.

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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