数量	产品目录编号	订购说明	数量 / 包装	公开价
			96-Well Plate

数量	产品目录编号	订购说明	数量 / 包装	公开价
	48-602MAG	Buffer Detection Kit for Magnetic Beads	1 Kit

MABC519 Sigma-AldrichAnti-Trop2, clone 2G10, Azide Free Antibody

This Anti-Trop2 antibody, clone 2G10, Azide Free is validated for use in ICC, flow cytometry & inhibition for the detection of Trop2.

Anti-Trop2, clone 2G10, Azide Free Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.

MSDS
分析证书

Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: TACSTD2, GA733-1, M1S1, TROP2 UniProt Number: P09758

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概述

Replacement Information

特卖

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重要规格表

Species Reactivity	Key Applications	Host	Format	Antibody Type
H	ICC, FC, Inhibition	M	Purified	Monoclonal Antibody

Description
Catalogue Number	MABC519
Description	Anti-Trop2, clone 2G10, Azide Free Antibody
Alternate Names	Tumor-associated calcium signal transducer 2 Cell surface glycoprotein Trop-2 Membrane component chromosome 1 surface marker 1 Pancreatic carcinoma marker protein GA733-1
Background Information	The protein known as Trop-2, or also known as cell surface glycoprotein Trop-2, Membrane component chromosome 1 surface marker 1 or Pancreatic carcinoma marker protein GA733-1 and encoded by the gene TACSTD2/GA733-1/M1S1/TROP2, is a protein that may function as a growth factor receptor and is expressed primarily in the placenta, lung and epithelial tissues but also found in certain cancers. The protein was first identified as a carcinoma antigen by the monoclonal GA733. It is a plasma membrane bound protein that transduces an intracellular calcium signal after binding unknown ligands. Mutations in Trop2 are associated with a rare eye disease leading to blindness. Trop-2 has also recently been shown to be important in regulating fibroblast motility and lung cell proliferation via the regulation of the ERK kinase pathway as well as several critical components of the cell migration apparatus.

References

Product Information
Format	Purified
Presentation	Purified mouse monoclonal IgG2aκ in buffer containing PBS without preservatives.
Quality Level	MQ100

Applications
Application	This Anti-Trop2 antibody, clone 2G10, Azide Free is validated for use in ICC, flow cytometry & inhibition for the detection of Trop2.
Key Applications	Immunocytochemistry Flow Cytometry Inhibition
Application Notes	Immunocytochemistry Analysis: A representative lot detected Trop2 in MTE 4-14/T2 and MCF7 cells (Prof. Saverio Alberti, Oncoxx Biotec.). Flow Cytometry Analysis: A representative lot detected Trop2 in transfected cells, Skov-3 cancer cells, and HT29 cancer cells (Prof. Saverio Alberti, Oncoxx Biotec.). Inhibition Analysis: A representative lot inhibited tumor growth in DU145 prostate cancer cells, and in HT-29, HCT116 and Colo205 cells. (Note: When used together, Cat. No. MABC519, Anti-Trop2, clone 2G10, Azide Free and Cat. No. MABC518, Anti-Trop2, clone 2EF, Azide Free maximizes inhibition of tumor growth in vivo.) (Prof. Saverio Alberti, Oncoxx Biotec.).

Biological Information
Immunogen	Recombinant protein corresponding to the extracellular domain of human Trop2.
Clone	2G10
Concentration	Please refer to the Certificate of Analysis for the lot-specific concentration.
Host	Mouse
Isotype	IgG2aκ
Species Reactivity	Human
Antibody Type	Monoclonal Antibody
Entrez Gene Number	NP_002344
Gene Symbol	TACSTD2 GA733-1 M1S1 TROP2
Purification Method	Protein G Purified
UniProt Number	P09758
Molecular Weight	36 kDa calculated

Physicochemical Information

Dimensions

Materials Information

Toxicological Information

Safety Information according to GHS

Safety Information

Product Usage Statements
Quality Assurance	Evaluated by Immunocytochemistry Analysis in MET cells transfected with a vector expressing Trop2 or with an empty vector. Immunocytochemistry Analysis: A 1:50 dilution of this antibody detected Trop 2 in MET cells transfected with a vector expressing Trop2 and not in MET cells transfected with an empty vector.
Usage Statement	Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Storage and Shipping Information
Storage Conditions	Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.

Packaging Information
Material Size	100 µg

Transport Information

Supplemental Information

Specifications

Global Trade Item Number
产品目录编号	GTIN
MABC519	04053252955860

Documentation

Anti-Trop2, clone 2G10, Azide Free Antibody MSDS

职位
物料安全数据表 (MSDS)

Anti-Trop2, clone 2G10, Azide Free Antibody 分析证书

标题	批号
Anti-Trop2, clone 2G10, Azide Free - Q2385777	Q2385777
Anti-Trop2, clone 2G10, Azide Free - 3305857	3305857
Anti-Trop2, clone 2G10, Azide Free - 3534053	3534053
Anti-Trop2, clone 2G10, Azide Free - 3698003	3698003
Anti-Trop2, clone 2G10, Azide Free - 3738438	3738438
Anti-Trop2, clone 2G10, Azide Free - 3915567	3915567
Anti-Trop2, clone 2G10, Azide Free - 3922569	3922569
Anti-Trop2, clone 2G10, Azide Free -2815150	2815150

种类

Life Science Research > Antibodies and Assays > Primary Antibodies

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