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MABN473 Anti-TMEM106B Antibody, clone TME-N 6F2

MABN473
100 µg  
Purchase on Sigma-Aldrich

特卖

概述

重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, RWB, IFRPurifiedMonoclonal Antibody
Description
Catalogue NumberMABN473
DescriptionAnti-TMEM106B Antibody, clone TME-N 6F2
Alternate Names
  • Transmembrane protein 106B
  • TMEM106B
Background InformationTransmembrane protein 106B (TMEM106B) is a single-pass type II membrane protein present in endosomal and lysosomal membranes, and is highly expressed in the frontal cortex. Increased TMEM106B expression in the brain may be linked to mechanisms of disease in frontotemporal lobar degeneration with TAR DNA-binding protein (TDP-43) inclusions (FTLD-TDP). Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia.
Product Information
FormatPurified
Control
  • Human cortex tissue lysate
PresentationPurified rat monoclonal IgG2c in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-TMEM106B, clone TME-N 6F2 detects levels of TMEM106B proteins & has been published & validated for use in WB & IF.
Key Applications
  • Western Blotting
  • Immunofluorescence
Application NotesImmunofluorescence Analysis: A 1:50 dilution from a representative lot detected TMEM106B in rat cerebellum tissue.
Biological Information
ImmunogenRecombinant protein corresponding to the N-terminus of human TMEM106B.
EpitopeN-terminus
CloneTME-N 6F2
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRat
SpecificityThis antibody recognizes the N-terminus of TMEM106B.
Species Reactivity
  • Human
  • Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • TMEM106B
Purification MethodProtein G Purified
UniProt Number
Molecular Weight~30 kDa observed (At higher antibody concentrations, this protein may be observed at ~45 kDa.). This protein may be observed at ~50 kDa due to glycosylation (Lang, C. M., et al. (2012). J Biol Chem. 287(23):19355-19365.).
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in human cortex tissue lysate.

Western Blot Analysis: 1 µg/mL of this antibody detected TMEM106B in 10 µg of human cortex tissue lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Global Trade Item Number
产品目录编号 GTIN
MABN473 04053252850929