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ABT142 Anti-PLK-4 Antibody

Anti-PLK-4 Antibody detects level of PLK-4 & has been published & validated for use in Western Blotting, ICC.

Anti-PLK-4 Antibody MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Cell Structure Research Sub-Category: Cytoskeleton Gene Symbol: PLK4, SAK, STK18 UniProt Number: O00444
ABT142
100 µg  
Purchase on Sigma-Aldrich

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概述

Replacement Information

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重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
H, M, RWB, ICCRbPurifiedPolyclonal Antibody
Description
Catalogue NumberABT142
DescriptionAnti-PLK-4 Antibody
Alternate Names
  • Serine/threonine-protein kinase PLK4
  • Polo-like kinase 4
  • PLK-4
  • Serine/threonine-protein kinase 18
  • Serine/threonine-protein kinase Sak
Background InformationSerine/threonine-protein kinase PLK4 (PLK-4) is a member of the protein kinase superfamily and plays an essential role in centriole duplication. PLK-4 triggers procentriole formation on the surface of the parental centriole cylinder, leading to the recruitment of centriole biogenesis proteins. It may be involved in tumorigenesis since centrosome aberrations are frequently observed in tumors. PLK-4 may also be involved in trophoblast differentiation by phosphorylating HAND1, leading to the disruption between HAND1 and MDFIC and then activating HAND1.
References
Product Information
FormatPurified
Control
  • Jurkat cell lysate
PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality LevelMQ100
Applications
ApplicationAnti-PLK-4 Antibody detects level of PLK-4 & has been published & validated for use in Western Blotting, ICC.
Key Applications
  • Western Blotting
  • Immunocytochemistry
Biological Information
ImmunogenKLH-conjugated linear peptide corresponding to the POLO box domain of human PLK-4.
EpitopePOLO box domain
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityThis antibody recognizes the POLO box domain of PLK-4
Species Reactivity
  • Human
  • Mouse
  • Rat
Antibody TypePolyclonal Antibody
Entrez Gene Number
Gene Symbol
  • PLK4
  • SAK
  • STK18
Purification MethodProtein A Purfied
UniProt Number
Molecular Weight~95 kDa observed
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Western Blot in Jurkat cell lysate.

Western Blot Analysis: 0.2 µg/mL of this antibody detected PLK-4 in 10 µg of Jurkat cell lysate.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
ABT142 04053252699726