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MABN1865-100UG Anti-NR3A Antibody, clone N416/40

Anti-NR3A, clone N416/40, Cat. No. MABN1865, is a mouse monoclonal antibody that detects NMDAR3A (NR3A) and has been tested for use in Immunohistochemistry (Paraffin).

MABN1865-100UG
100 μg  
Purchase on Sigma-Aldrich

概述

Replacement Information
Description
Catalogue NumberMABN1865-100UG
DescriptionAnti-NR3A Antibody, clone N416/40
Alternate Names
  • NR3A
  • NMDAR3A
  • N-methyl-D-aspartate receptor subtype 3A
Background InformationGlutamate receptor ionotropic, NMDA3A (UniProt: A2AIR5; also known as NR3A) is encoded by the Grin3a gene (Gene ID: 242443) in murine species. NR3A is a member of the glutamate-gated ion channel family. NMDA receptor complexes are ligand-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. They are involved in long-term potentiation and neuronal plasticity and regulate the number of nerve cells during development. However, over-stimulation NMDA receptors can lead to neuronal degeneration. The NMDA-receptor-channels display relatively higher Ca2+ permeability than the non-NMDA ionotropic receptors and can be blocked by Mg2+ in a voltage- dependent manner. NR3A is widely distributed and displays reduced single-channel conductance, low calcium permeability and low voltage-dependent sensitivity to magnesium. It is believed to play a role in the development of dendritic spines. NR3A is a multi-pass post-synaptic membrane protein that is synthesized with a signal peptide (aa 1-26), which is subsequently cleaved off to generate the mature form that has four transmembrane domains (aa 675-695; 716-734; 746-769; and 934-956).
References
Product Information
FormatPurified
PresentationPurified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
ApplicationAnti-NR3A, clone N416/40, Cat. No. MABN1865, is a mouse monoclonal antibody that detects NMDAR3A (NR3A) and has been tested for use in Immunohistochemistry (Paraffin).
Key Applications
  • Immunohistochemistry (Paraffin)
Biological Information
ImmunogenLinear peptide from the N-terminal region of mouse Glutamate receptor ionotropic, NMDA3A (NR3A).
Epitopeextracellular domain
CloneN416/40
ConcentrationPlease refer to lot specific datasheet.
HostMouse
SpecificityClone N416/40 is a mouse monoclonal antibody that detects NMDAR3A (NR3A).
IsotypeIgG2aκ
Species Reactivity
  • Rat
  • Mouse
Species Reactivity NoteMouse, Rat
Antibody TypeMonoclonal Antibody
Entrez Gene Number
Gene Symbol
  • Grin3a
Purification MethodProtein G purified
UniProt Number
Molecular Weight127.54 kDa calculated.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Quality AssuranceEvaluated by Immunohistochemistry (Paraffin) in rat brain tissue sections.

Immunohistochemistry (Paraffin) Analysis: A 1:50 dilution of this antibody detected NR3A in rat brain tissue sections.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
Packaging Information
Material Size100 μg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
MABN1865-100UG 04061841276661