Millipore Sigma Vibrant Logo
Attention: We have moved. Merck Millipore products are no longer available for purchase on MerckMillipore.com.Learn More

AB9452 Anti-Muscarinic Acetylcholine Receptor M2 Antibody

Detect Muscarinic Acetylcholine Receptor M2 using this Anti-Muscarinic Acetylcholine Receptor M2 Antibody validated for use in IH(P).

MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: CHRM2, MGC120006, FLJ43243, MGC120007, HM2 UniProt Number: P08172
AB9452
50 µg  
Purchase on Sigma-Aldrich

特卖

概述

Replacement Information

特卖

100% Performance Guaranteed

重要规格表

Species ReactivityKey ApplicationsHostFormatAntibody Type
HIH(P)RbAffinity PurifiedPolyclonal Antibody
Description
Catalogue NumberAB9452
Brand Family Chemicon®
Trade Name
  • Chemicon
DescriptionAnti-Muscarinic Acetylcholine Receptor M2 Antibody
References
Product Information
FormatAffinity Purified
PresentationAffinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
Quality LevelMQ100
Applications
ApplicationDetect Muscarinic Acetylcholine Receptor M2 using this Anti-Muscarinic Acetylcholine Receptor M2 Antibody validated for use in IH(P).
Key Applications
  • Immunohistochemistry (Paraffin)
Application NotesImmunohistochemistry on formalin-fixed, paraffin-embedded tissue sections.

Optimal working dilutions must be determined by the end user.
Biological Information
ImmunogenSynthetic peptide from the 3rd cytoplasmic domain of human Muscarinic Acetylcholine Receptor M2.
ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
HostRabbit
SpecificityRecognizes Muscarinic Acetylcholine Receptor M2.
Species Reactivity
  • Human
Antibody TypePolyclonal Antibody
Entrez Gene Number
Entrez Gene SummaryThe muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
Gene Symbol
  • CHRM2
  • MGC120006
  • FLJ43243
  • MGC120007
  • HM2
UniProt Number
UniProt SummaryFUNCTION: SwissProt: P08172 # The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition.
SIZE: 466 amino acids; 51715 Da
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
SIMILARITY: SwissProt: P08172 ## Belongs to the G-protein coupled receptor 1 family.
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Availability by Geography
  • This product is not available for sale in Japan.
Usage Statement
  • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Storage and Shipping Information
Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
Packaging Information
Material Size50 µg
Transport Information
Supplemental Information
Specifications
Global Trade Item Number
产品目录编号 GTIN
AB9452 04053252733482